Main description:

The only available text to focus primarily on Acute Respiratory Distress Syndrome (ARDS).

Thoroughly revised content and ten new chapters provide pulmonologists with the latest developments and applications of pharmacological and mechanical therapies needed to treat the debilitating and difficult condition of ARDS.

Highlights include:

the definition, epidemiology, pathology, and pathogenesis of ARDS
complications such as transfusion-related injury, and endothelium and vascular dysfunction
the long-term outcomes of ARDS
host defense and infection
the latest developments in ARDS therapy: glucocorticoid therapy, surfactant therapy, mechanical ventilation, and mesenchymal stem cells
predictive factors: gene expression profiling and biomarkers, and chemokines and cytokines
advances in management strategies: fluid management, non-pulmonary and non-sepsis management, and glucose control

Contents:

Definitions and Clinical Risk Factors. Epidemiology of Acute Lung Injury: A Public Health Perspective. Radiographic Findings of the Acute Respiratory Distress Syndrome. Pulmonary Pathology of ARDS: Diffuse Alveolar Damage. Pathogenesis of Acute Lung Injury: Experimental Studies. Pathogenesis of Acute Lung Injury: Clinical Studies. Apoptosis in the Pathogenesis and Resolution of Acute Lung Injury. Pathogenesis of Ventilator-Induced Lung Injury. Sepsis in the Acute Respiratory Distress Syndrome: Treatment Implications. Transfusion-Related Acute Lung Injury. Mechanisms of Fibroproliferation in Acute Lung Injury. Current Approaches and Recent Advances in the Genetic Epidemiology of Acute Lung Injury/Acute Respiratory Distress Syndrome. Gene Expression Profiling and Biomarkers in ARDS. Resolution of Alveolar Edema: Mechanisms and Relationship to Clinical Acute Lung Injury. Lung Vascular Dysfunction and Repair in Acute Lung Injury: Role of the Endothelial Cytoskeleton. Surfactant Therapy in the Acute Respiratory Distress Syndrome. Prone Position in ARDS. Mechanical Ventilation in the Acute Respiratory Distress Syndrome. Fluid Therapy and HemodynamicMonitoring in Acute Lung Injury. Pathogenesis of Sepsis and Sepsis-Induced Acute Lung Injury. Cell-Based Therapy for Acute Lung Injury and Acute Respiratory Distress Syndrome. Chemokines and Cytokines in ARDS.