Main description:

Bringing together a
distinguished interdisciplinary team of contributors, this volume
provides a comprehensive exploration of translational toxicology-a systematic
approach to developing therapeutic interventions that can protect against,
mitigate, or reverse the effects of exposures. In particular, the book
addresses modes of action and biomarkers, developmental risks of exposures, and
potential translational toxicology therapeutics. The result is a compelling
application of developmental toxicology in a new therapeutic discipline that is
destined to become part of standard medical practice.

Translational
Toxicology: Defining a New Therapeutic Discipline is an essential text for regulatory authorities, scientists, and
physicians who are concerned with environmental exposures, public health, nutrition,
and pharmaceutical research and development. Basic science, epidemiological,
and clinical investigators will also find this book a significant resource.

Contents:

I.Introduction.- The Opportunity to Translate Developmental Toxicology into a Therapeutic Discipline.- The
Role of Toxicokinetics and Toxicodynamics in Developmental and Translational
Toxicology.- II.Toxicant Modes of Action and Biomarkers.- Mutational Effects.- Ligand-Mediated Toxicology: Characterization and Translational Prospects.- Effects of Environmentally Acquired Heavy Metals and Nutrients on the Epigenome and Phenotype.- Fetal Imaging and Effects of Exposures on Growth and Function.- III.Developmental Risks of Exposures and Potential Translational Toxicology Therapeutics.- Ovarian Toxicity of Environmental Contaminants: 50 Shades of Grey.- The
"Toxic" Effects of a Perinatal Obesogenic Environment: Maternal Obesity and
Impacts on Future Generations.- The Role of Environmental Exposures in Preterm Birth.- The Impact of Environmental Stressors on DNA Methylation, Neurobehavioral Development and Chronic Physical Aggression: Prospects for Early Protective Interventions.- Coffee Health Effects from Early Fetal Development through Childhood and Adolescence.