Main description:

The application of molecular biologic methods, recognition of neurogenic inflammatory processes, and utilization of genetic knockout animals are just some of the advances in toxicology of the upper airways in recent years. Toxicology of the Nose and Upper Airways presents a culmination of knowledge gained as a result of both human and experimental animal studies over the past decade. With contributions from internationally recognized leaders in the fields of experimental toxicology, respiratory medicine, otolaryngology, allergy, and sensory science, this volume:

Examines the effect of selected pollutants on the upper airways of both humans and experimental animals-emphasizing mechanistic issues in the process

Discusses epidemiologic findings from populations exposed occupationally or environmentally, comparing and contrasting alternative risk assessment approaches

Features clear chapter organization with sections on structure and function, dosimetry and toxicokinetics, functional and pathologic responses and their measurement, responses to specific agents, risk assessment, and special topics

This volume is an essential reference for pharmacologists and toxicologists concerned with the nose and upper airway, as well as clinicians, risk assessors, and sensory scientists.

Contents:

Structure & function in the upper airway

Functional anatomy of the upper airway in experimental animals

Functional anatomy of the upper airway in humans

Functional neuroanatomy of the upper airway in experimental animals

Functional neuroanatomy of the human upper airway

Mucosal enzymology of the upper airway. Dosimetry & Toxicokinetics of Nasal Exposure

Upper airway dosimetry of gases, vapors and particulate matter in experimental animals

Upper airway dosimetry of gases and vapors in humans

Upper airway dosimetry of particulate matter in humans. Functional & Pathologic Responses and Their Measurement

Exposure and recording systems in human studies

Biomarkers of nasal toxicity in experimental animals

Biomarkers of nasal toxicity in humans

Nasal reflexes - including alterations in respiratory behavior - in experimental animals

Nasal chemosensory irritation in humans

Nasal reflexes in humans

Olfactory toxicity in humans and experimental animals

Inflammatory conditions of the nose and paranasal sinuses in experimental animals

Inflammatory conditions of the nose and paranasal sinuses in humans

Chronic tissue changes and carcinogenesis in the upper airway. Responses to Specific Agents

Second hand tobacco smoke exposure in humans

Chlorine exposure in humans and experimental animals

Hydrogen sulfide exposure in experimental animals

Sulfur dioxide exposure in humans

Exposure to volatile organic compounds in humans. Risk Assessment and Special Topics

Benchmark dose and noncancer risk assessment for the upper airways

Physico-chemical modeling of sensory irritation in humans and experimental animals

Effect of allergic inflammation on irritant responsiveness in the upper airwa