Main description:

The gastrointestinal tract is the most important of the three major routes of entry (and clearance) of xenobiotics and biologic entities into the bodies of mammals. As such, it is also the major route for administration of pharmaceuticals to humans. Gastrointestinal Toxicology, Second Edition describes the mechanism for entry and clearance of xenobiotics, as well as the barriers, immunologic and metabolic issues, and functions present in the GI tract.

Appearing in this volume are also considerations of the microbiome and its actions and influence on the function of the GI tract and on the toxicity and pharmacodynamics of ingested substances (including nutrients, toxins, and therapeutics). These fifteen chapters written by experienced experts in the field address methods to evaluate GI function; specifics of GI function and toxicity assessment in canines and minipigs; classes of compounds with their toxicity; species differences; and the toxicity (and promise) of nanoparticles. Those needing to understand the structure, function, and methods of studying the GI tract will find this volume a singular source of reference.

Contents:

Preface

Editor

Contributors

Chapter 1 Introduction: The Gastrointestinal (GI) Tract as a Barrier and as an Absorptive and Metabolic Organ

Shayne C. Gad

Chapter 2 Methods for the Analysis of Gastrointestinal Function

Robin C. Guy

Chapter 3 Safety Pharmacology and the GI Tract

Henry I. Jacoby

Chapter 4 Gastrointestinal Tract Development and Its Importance in Toxicology

Alma M. Feldpausch, Joseph V. Rodricks, Rosalind A. Schoof and Brittany A. Weldon

Chapter 5 Gastrointestinal Tract as a Major Route of Pharmaceutical Administration

Robert W. Kapp, Jr.

Chapter 6 Gastrointestinal Function and Toxicology in Canines

Charles B. Spainhour

Chapter 7 Gastrointestinal Function and Toxicology in Minipigs

Maria R. Jones and Alain Stricker-Krongrad

Chapter 8 Absorption of Macromolecules by Mammalian Intestinal Epithelium

Shayne C. Gad

Chapter 9 Peyer's Patch Epithelium: An Imperfect Barrier and Effect of the Microbiome

Gary R. Burleson and Florence G. Burleson

Chapter 10 Alteration of Intestinal Function by Xenobiotic Exposure: Animal Models

Shayne C. Gad

Chapter 11 The Role of the Microbiome on Metabolism, Absorption, and Toxicity of Xenobiotics in the Gastrointestinal Tract

Shayne C. Gad

Chapter 12 Normal and Abnormal Intestinal Absorption by Humans

David W. Hobson and Valerie L. Hobson Balldin

Chapter 13 Classes of Compounds with GI Tract Toxicity

Amy L. Mihalchik and Erica N. Rogers

Chapter 14 Species Differences in GI Toxicity

Shayne C. Gad

Chapter 15 Nanoparticles in the Gastrointestinal Tract

David W. Hobson and Valerie L. Hobson Balldin

Index