Main description:

Glycobiology is an emerging field of studying glycans (sugars) and glycoconjugates that are essentially involved in almost all biological processes, from fine-tuning glycoprotein function to protein-protein interactions, signaling, immune response, host-pathogen interactions, etc. However, due to structural complexity of glycans and analytical challenges this exciting field was lagging behind other areas of biology. With technological advancements growing number of glycans' functions are being discovered and the study of glycans is becoming a cutting-edge discipline in basic and clinical research.
Despite recent developments in glycobiology field, many aspects of glycosylation process still remain unknown, both in a healthy human organism and in pathological states. Human glycome is dynamic and changes with physiological triggers, immune challenges and disease. Atypical glycosylation is consequently a subject of disease biomarker research, and a target for therapeutic interventions. On the other hand, properties of glycosylated biotherapeutics are predominantly determined by their glycans.
The Role of Glycosylation in Health and Disease provides a comprehensive overview of types and functions of glycans in a healthy human organism as well as their role in pathophysiology of different diseases and efficiency of glycosylated biotherapeutics. Written by the experts in the field, this book aims to bring glycobiology field closer to students, researchers in life sciences and professionals in biopharmaceutical industry.

Contents:

Part I: Importance and functions of the human glycome1. N-glycosylation (Tetsuya Hirata, Yasuhiko Kizuka)2. Mucin type O-GalNAc glycosylation in health and disease (Ieva Bagdonaite, Emil M. H. Pallesen, Mathias I. Nielsen, Hans H. Wandall)3. Glycosphingolipids (Elena Chiricozzi, Massimo Aureli, Laura Mauri, Erika Di Biase, Giulia Lunghi, Maria Fazzari, Manuela Valsecchi, Emma Veronica Carsana, Nicoletta Loberto, Alessandro Prinetti, Sandro Sonnino)4. Glycosaminoglycans (Yuefan Song, Fuming Zhang, Robert J. Linhardt)5. Other types of glycosylation (Yohei Tsukamoto, Hideyuki Takeuchi)6. Extracellular vesicles and glycosylation (Yoichiro Harada, Yuki Ohkawa, Kento Maeda, Yasuhiko Kizuka, Naoyuki Taniguchi)7. Quantitative genetics of human protein N-glycosylation (Jasminka Kristic, Sodbo Zh. Sharapov, Yurii S. Aulchenko)8. Epigenetic regulation of glycosylation (Rossella Indellicato, Marco Trinchera)
Part II: Glycosylation in disease9. Glycosaminoglycans in neurodegenerative diseases (Weihua Jin, Fuming Zhang, Robert J. Linhardt)10. Glycosylation in autoimmune diseases (Marta Zabczynska, Pawel Link-Lenczowski, Ewa Pochec)11. The role of glycosylation in infectious diseases (Xiao-Lian Zhang, Haoran Qu)12. The importance of glycosylation in COVID-19 infection (Tea Petrovic, Gordan Lauc, Irena Trbojevic-Akmacic)13. The role of glycosylation in inflammatory diseases (Ines Alves, Manuel M. Vicente, Ana M. Dias, Joana Gaifem, Claudia Rodrigues, Ana Campar, Salome S. Pinho)14. Protein glycosylation in diabetes (Tamara Stambuk, Olga Gornik)15. Glycosylation and cardiovascular diseases (Hesam Dashti, Maria Angelica Pabon Porras, Samia Mora)16. Glycosylation profiling as a biomarker of suboptimal health for chronic disease stratification (Xueqing Wang, Zhaohua Zhong, Lois Balmer, Wei Wang)17. Glycosylation and aging (Ana Cindric, Jasminka Kristic, Marina Martinic Kavur, Marija Pezer)