Main description:

Translational control in the nervous system is important. Many physiological processes in the nervous system depend on accurate control of the proteome that is mediated through protein synthetic mechanisms and thus, the nervous system is very sensitive to dysregulation of translational control. The Oxford Handbook of Neuronal Protein Synthesis reviews the mechanisms of translational control used by the nervous system, as well as how important nervous system
functions, such as plasticity and homeostasis, depend on accurate translational control. The handbook extensively covers how dysregulation of protein synthesis can manifest itself in many distinct pathological processes including neurodevelopmental, neuropsychiatric, and neurodegenerative diseases. The
handbook is comprehensive in its coverage of translational control mechanisms with particular focus on how these general control mechanisms are specifically utilized in the context of the cell biological constraints of the nervous system from both a mechanistic and systems perspective.

Contents:

Part I: Role of Translation Factors

1. Regulation of Protein Synthesis by eIF4E in the Brain
Kleanthi Chalkiadaki, Stella Kouloulia, Clive R. Bramham, and Christos G. Gkogkas

2. Translational Control Through the eIF4E Binding Proteins in the Brain
Argel Aguilar-Valles, Edna Matta-Camacho, and Nahum Sonenberg

3. The Integrated Stress Response in Memory and Cognitive Disorders
Jacqunae L. Mays and Mauro Costa-Mattioli

4. The Role of the Eukaryotic Elongation Factor 2 (eEF2) Pathway in Neuronal Function
Elham Taha and Kobi Rosenblum

5. Sidekick No More: Neural Translation Control by p70 ribosomal S6 kinase 1
Aditi Bhattacharya

Part II: Role of Specific Elements in the mRNA

6. Dendritic Targeting and Regulatory RNA Control of Local Neuronal Translation
Taesun Eom, Ilham A. Muslimov, Anna Iacoangeli, and Henri Tiedge

7. Internal Ribosome Entry Site-Mediated Translation in Neuronal Protein Synthesis
Martin Holcik

8. RNA Modifications in the Central Nervous System
Dan Ohtan Wang

9. Role of CPEB-Family Proteins in Memory
Kausik Si

10. FMRP and MicroRNAs in Neuronal Protein Synthesis
Monica C. Lannom and Stephanie Ceman

11. Focusing on mRNA Granules and Stalled Polysomes Amidst Diverse Mechanisms Underlying mRNA Transport, mRNA Storage and Local Translation
Mina N. Anadolu and Wayne S. Sossin

Part III: Physiological Roles of Translation

12. Protein Synthesis and Synapse Specificity in Functional Plasticity
Radha Raghuraman, Amrita Benoy, and Sreedharan Sajikumar

13. Regulation of Synaptic Homeostasis by Translational Mechanisms
Megumi Mori, Jay Penney, and Pejmun Haghighi

14. Multiple Roles of RNA Regulatory Factors in Neuronal Development and Function in C. elegans
Matthew G. Andrusiak and Yishi Jin

15. Regulation of mRNA Translation in Axons
Priyanka Patel, Pabitra K. Sahoo, Amar N. Kar, and Jeffery L. Twiss

16. Protein Synthesis and Translational Control in Neural Stem Cell Development and Neurogenesis
Lamees Mohammad, Joscelyn Wiseman, Sarah Erickson, and Guang Yang

Part IV: Neuronal Protein Synthesis and Disease

17. Translational Controls in Pain
Sarah Loerch, June Bryan De La Pena, Jane Song, Joseph J. Pancrazio, Theodore J. Price, and Zachary T. Campbell

18. Dysregulated Translation in Autism Spectrum Disorder
Emanuela Santini and Anders Borgkvist

19. Neuronal mRNA Translation in Addiction
Emma Puighermanal and Emmanuel Valjent

20. Dysregulated Protein Synthesis in Major Depression Disorder
Chelcie F. Heaney and Kimberly F. Raab-Graham

21. Dysregulation of Neuronal Protein Synthesis in Alzheimer's Disease
Tao Ma

22. RNA-Binding Proteins and Translation in Neurodegenerative Disease
Kent E. Duncan

23. Role of Eukaryotic Initiation Factor eIF2B in Vanishing White Matter Disease
Truus E. M. Abbink, Lisanne E. Wisse, Xuemin Wang, and Christopher G. Proud

Index