Within the past two decades, extraordinary new functions for the nucleolus have begun to appear, giving the field a new vitality and generating renewed excitement and interest. These new discoveries include both newly-discovered functions and aspects of its conventional role. The Nucleolus is divided into three parts: nucleolar structure and organization, the role of the nucleolus in ribosome biogenesis, and novel functions of the nucleolus.
Covers recent discoveries on novel functions of the nucleolus.
Emphasizes nucleolar proteins while also including the crucial importance of nucleic acids.
Includes chapters on nucleolar ultrastructure, the locations and dynamics of nucleolar components, and on regulatory systems.
Within the past two decades, extraordinary new functions for the nucleolus have begun to appear, giving the field a new vitality and generating renewed excitement and interest. These new discoveries include not only the novel functions of the nucleouls, but also numerous breakthroughs on its conventional role. Consequently, a large part of this volume is devoted to traditional functions of the nucleolus. Recent research has led to so much information that the subject cannot be fully contained within one volume, so this book has focused on recent progress in specialized topics within the general subject.
<i>The Nucleolus</i> is divided into three parts: nucleolar structure and organization, the role of the nucleolus in ribosome biogenesis, and novel functions of the nucleolus. Proteomics has shown that there are hundreds of proteins of unknown function in the nucleolus, which are likely to keep researchers busy for years. In addition, the roles of many viral components in the nucleolus will continue to intrigue us, hopefully moving beyond the phenomenology that is now the case with many viral components in the nucleolus. Even now, there is already evidence that we can take advantage of our knowledge of the nucleolus to develop therapeutic strategies, and this book hopes to help build the path to a new era of nucleolar translational medical research.
Part 1: Nucleolar Structure and Organization
1. Structural organization of the nucleolus as a consequence of the dynamics of ribosome biogenesis
2. The dynamic proteome of the nucleolus
François-Michel Boisvert, Yasmeen Ahmad, Angus I. Lamond
3. The Structure of rDNA Chromatin
Peter C McKeown, Peter J Shaw
4. The epigenetics of the nucleolus: structure and function of active and silent ribosomal RNA genes
5. UBF, an Essential Player in Maintenance of Active NORs and nucleolar formation
Alice Grob, Christine Colleran, Brian McStay
Part 2: Role of the Nucleolus in Ribosome Biogenesis
6. The RNA Polymerase I Transcription Machinery
Renate Voit, Ingrid Grummt
7. Small Ribonucleoproteins in Ribosome Biogenesis
Franziska Bleichert, Susan Baserga
8. Crosstalk between ribosome synthesis and cell cycle progression and its potential implications in human genetic disease
Marie Gérus, Michèle Caizergues-Ferrer, Yves Henry, Anthony Henras
9. The multiple properties and functions of nucleolin
Rong Cong, Sadhan Das, Philippe Bouvet
10. The multifunctional nucleolar protein nucleophosmin/NPM/B23 and the nucleoplasmin family of proteins
Shea Ping Yip, Parco M. Siu, Polly H.M. Leung, Yanxiang Zhao, Benjamin Y.M Yung
11. Structure and function of NOPP140 and treacle
Fang He, Patrick DiMario
Part 3: Novel Functions of the Nucleolus
12. Chapter 12. The Role of the Nucleolus in the Stress Response
Laura A. Tollini, Rebecca A. Frum, Yanping Zhang
13. New Frontiers in Nucleolar Research - Nucleostemin and Related Proteins
14. Viruses and the Nucleolus
David Matthews, Edward Emmott, Julian Hiscox
15. Assembly of Signal Recognition Particles in the Nucleolus
16. Relationship of the Cajal Body to the Nucleolus
Andrew Gilder, Michael Hebert
17. Role of the Nucleolus in HIV Infection and Therapy
Jerlisa Arizala, John Rossi