Main description:

This is a broad–ranging review of the current research on Alzheimer′s disease and other dementias from both basic neuroscience and clinical perspectives. It provides scientists and medical professionals with an extensive introduction and an up–to–date review of cutting–edge scientific advances.

This reference begins with an introduction to and overview of the major dementias including Alzheimer′s Disease, Dementia with Lewy Bodies, Frontotemporal Dementia, and Vascular Dementia and explores pathology, manifestations, treatment, and other necessary background information. The second section explores the state–of–the–art research on specific disease mechanisms relevant to dementia such as neuropathology and epidemiology, and genetic risk factors. The third section examines the most recent research on major topics in cognitive and behavioral neuroscience as it relates to dementia, and the final section explores the latest research in neuroimaging.

No other reference encompasses the range of topics presented, or combines basic molecular perspectives and cognitive neurosciences. It is an essential tool for physicians and medical students, psychologists, scientists, and allied health professionals including nurses, social workers, and therapists.

Back cover:

This is a broad–ranging review of the current research on Alzheimer′s disease and other dementias from both basic neuroscience and clinical perspectives. It provides scientists and medical professionals with an extensive introduction and an up–to–date review of cutting–edge scientific advances.

This reference begins with an introduction to and overview of the major dementias including Alzheimer′s Disease, Dementia with Lewy Bodies, Frontotemporal Dementia, and Vascular Dementia and explores pathology, manifestations, treatment, and other necessary background information. The second section explores the state–of–the–art research on specific disease mechanisms relevant to dementia such as neuropathology and epidemiology, and genetic risk factors. The third section examines the most recent research on major topics in cognitive and behavioral neuroscience as it relates to dementia, and the final section explores the latest research in neuroimaging.

No other reference encompasses the range of topics presented, or combines basic molecular perspectives and cognitive neurosciences. It is an essential tool for physicians and medical students, psychologists, scientists, and allied health professionals including nurses, social workers, and therapists.

Contents:

Contributors ix

Foreword xii

Preface xv

Part I Common Dementias 1

1 Alzheimer s Disease 3
Alan M. Mandell and Robert C. Green

2 Vascular Dementia 92
Angela L. Jefferson, Amanda M. Gentile, and Ravi Kahlon

3 Dementia with Lewy Bodies 131
Tamara G. Fong and Daniel Z. Press

4 Frontotemporal Dementia 145
Adam L. Boxer

5 Other Dementias 179
Peter Morin

Part II Pathogenesis and Disease Mechanisms 195

6 Genetic Risk Factors for Dementia 197
Paul Hollingworth and Julie Williams

7 The Neuropathology of the Dementing Disorders 235
Ann C. McKee and Brandon E. Gavett

8 Amyloid Beta Peptide and the Amyloid Cascade Hypothesis 262
Carmela R. Abraham

9 Other Mechanisms of Neurodegeneration 277
Marina Boziki, Vassilis Papaliagkas, and Magda Tsolaki

10 Rational Therapeutics for Alzheimer s Disease and Other Dementias 301
Neil W. Kowall

Part III Cognitive and Behavioral Dysfunction 313

11 Memory Dysfunction in Dementia 315
Andrew E. Budson

12 Language Processing in Dementia 336
Jamie Reilly, Joshua Troche, and Murray Grossman

13 Executive Functioning 369
Robert A. Stern, Stacy L. Andersen, and Brandon E. Gavett

14 Emotion and Behavior in Alzheimer s Disease and Other Dementias 416
Christopher I. Wright

15 Visuospatial Function in Alzheimer s Disease and Related Disorders 457
Alice Cronin–Golomb

16 Sleep and Circadian Rhythms in Dementia 483
David G. Harper

Part IV Neuroimaging in Dementia 505

17 Glimpses of the Living Brain with Alzheimer s Disease 507
Ronald J. Killiany

18 Functional MRI in Alzheimer s Disease and Other Dementias 535
Maija Pihlajamäki and Reisa A. Sperling

19 Molecular Neuroimaging of the Dementias 557
Bradford C. Dickerson

20 Using EEG and MEG to Understand Brain Physiology in Alzheimer s Disease and Related Dementias 575
Brandon A. Ally

Index 604

Plate section between pages 304 and 305