Main description:

This title includes a number of Open Access chapters.

This new volume on gene expression and epigenetics discusses environmental effects related to specific gene expression. The book also shows methods for bioinformatic analysis of the epigenome. The book is broken into two sections: the first looks at eukaryotic DNA methylation and the second addresses how to integrate genomic medicine into clinical practice.

The book includes chapters on these topics:

* Gene expression in colon cancer tissue

* Epigenetics in human acute kidney injury

* Embryologically relevant candidate genes in MRKH patients

* DNA methylation in common skeletal disorders

* Causal relationships in genomics

* Predicting severe asthma exacerbations in children

* Epigenetic understanding of gene-environment interactions in psychiatric disorders

Contents:

Introduction. Part I: Eukaryotic DNA Methylation. Renal Kallikrein Excretion and Epigenetics in Human Acute Kidney Injury: Expression, Mechanisms and Consequences. COX-2 Gene Expression in Colon Cancer Tissue Related to Regulating Factors and Promoter Methylation Status. Down-Regulation of Promoter Methylation Level of CD4 Gene After MDV Infection in MD-Susceptible Chicken Line. A Combination of Transcriptome and Methylation Analyses Reveals Embryologically Relevant Candidate Genes in MRKH Patients. The Role of DNA Methylation in Common Skeletal Disorders. Enrichment-Based DNA Methylation Analysis Using Next-Generation Sequencing: Sample Exclusion, Estimating Changes in Global Methylation, and the Contribution of Replicate Lanes. Part II: Integrating Genomic Medicine into the Clinical Practice. Assessing Causal Relationships in Genomics: From Bradford-Hill Criteria to Complex Gene-Environment Interactions and Directed Acyclic Graphs. Genome Wide Association Study to Predict Severe Asthma Exacerbations in Children Using Random Forests Classifiers. Potential Utility of Natural Products as Regulators of Breast Cancer-Associated Aromatase Promoters. Therapeutic Potential of Cladribine in Combination with STAT3 Inhibitor Against Multiple Myeloma. Epigenetic Understanding of Gene-Environment Interactions in Psychiatric Disorders: A New Concept of Clinical Genetics. An Imprinted Rheumatoid Arthritis Methylome Signature Reflects Pathogenic Phenotype. Index.