Main description:

The volume features current basic, clinical, and translational research on aspects of skeletal morphogenesis and remodeling in health and disease. Papers survey vital new insights into the mechanisms of bone development and restructuring, including cellular and mechanical triggers, receptors and signaling pathways. Also covered are the effects of other physiological systems and disease states, such as immune system inflammation, diabetes, infection, and cancer on musculoskeletal health. Recent findings are shaping therapeutic directions that focus on both anti-resorptive and anabolic therapies. Basic scientists, clinical investigators, and clinicians with interests spanning endocrinology, physiology, cell biology, pathology, genetics, molecular biology, rheumatology, oncology, and other areas that relate to bone development and homeostasis will find this a valuable resource for the most recent developments in skeletal biology and medicine. This volume presents manuscripts stemming from the 4th New York Skeletal Biology and Medicine Conference, held at Mount Sinai School of Medicine in New York City on April 27 30, 2011.
The papers included in this volume include two of the topic areas presented at the conference; the other topic areas are included in Skeletal Biology and Medicine II. NOTE: Annals volumes are available for sale as individual books or as a journal. For information about institutional journal subscriptions, please visit http://ordering.onlinelibrary.wiley.com/subs.asp?ref=1749-6632&doi=10.1111/(ISSN)1749-6632. ACADEMY MEMBERS: Please contact the New York Academy of Sciences directly to place your order (www.nyas.org). Members of the New York Academy of Science receive full-text access to Annals online and discounts on print volumes. Please visit http://www.nyas.org/MemberCenter/Join.aspx for more information about becoming a member.

Contents:

The 2nd Conference on Skeletal Medicine and Biology: Special Features: Mone Zaidi. Historical Reflections and the Future: Iain MacIntyre.

Part I: Bone and Blood Vessels:.

1. Oxygen Sensing and Osteogenesis: Ying Wang, Chao Wan, Shawn R. Gilbert, and Thomas L. Clemens.

2. Perspective: The Osteoclast: An Angiogenic Cell?: Frank C. Cackowski and G. David Roodman.

3. Fetal Growth Plate: A Developmental Model of Cellular Adaptation to Hypoxia: Sylvain Provot and Ernestina Schipani.

4. Vascular Bmp-Msx2-Wnt Signaling And Oxidative Stress In Arterial Calcification: Jian-Su Shao, Ziyad Al Aly, Chung-Fang Lai, Su-Li Cheng, Jun Cai, Emily Huang, Abe Behrmann, and Dwight A. Towler.

5. Hypoxia-Mediated Mitochondrial Stress in RAW 264.7 Cells Induces Osteoclast-Like TRAP Positive Cells: Satish Srinivasan, and Narayan G. Avadhani.

6. Stem Cell Therapy in Bone Repair and Regeneration: Neeha Zaidi and Alan J. Nixon.

7. Fluid Shear Stress Up-regulates Vascular Endothelial Growth Factor Gene Expression in Osteoblasts: Mia M. Thi, Dumitru A. Iacobas, Sanda Iacobas, and David C. Spray.

Part II: Skeltal Immunity and Inflamation:.

8. B Lymphocytes and the Skeleton: Mark C. Horowitz.

9. Vitamin D in Defense of the Human Immune Response: John S. Adams, Philip T. Liu, Rene Chun, Robert L. Modlin, and Martin Hewison.

10. MRI and Quantification of Draining Lymph Node Function in Inflammatory Arthritis: Steven T. Proulx, Edmund Kwok, Zhigang You, Christopher A. Beck, David J. Shealy, Christopher T. Ritchlin, Brendan F. Boyce, Lianping Xing, and Edward M.Schwarz.

11. Perfusion Abnormalities in Subchondral Bone Associated with Marrow Edema, Osteoarthritis, and Avascular Necrosis: Roy K. Aaron, Jonathan P. Dyke, Deborah McK. Ciombor, Glenn A. Tung.

12. Nuclear Factor of Activated T cell Mediates Proinflamatory Gene Expression in Response to Mechanotransduction: Ayse B. Celil Aydemir, Stephenie Lee, Dae Won Kim, Thomas R. Gardner, Daniel Prince, Jae Mok Ahn, and Francis Young-In Lee.

13. Orthopaedic Implant Particle-Induced Tumor Necrosis Factor- Production in Macrophage/Monocyte Lineage Cells is Mediated by Nuclear Factor of Activated T cells: Hiroshi Minematsu, Mike J. Shin, Ayse B. Celil Aydemir, Sung Wook Seo,Dae Won Kim, Theodore A. Blaine, Fernando Macian, Jay Yang, Francis Young-In Lee.

14. ERK Signaling Regulates M-CSF Expression Induced By Titanium Particles In MC3T3.E1 Murine Calvarial Preosteoblastic Cells.

15. Sung W. Seo, Daniel Lee, Samuel K Cho, Abraham D. Kim, Hiroshi Minematsu, Ayse B. Cecil Aydemir, Jeffrey A. Geller, William Macaulay, Jay Yang, Francis Y. Lee.

16. Synovial Fluid Fibroblasts and Lymphocytes Support the Osteoclastogenesis in Human Psoriatic Arthritis: Giorgio Mori, Francesco P. Cantatore, Giacomina Brunetti, Angela Oranger, Graziana Colaianni, Laura Quarta, Addolorata Corrado, Silvia Colucci, and Maria Grano.

17. Molecular and Histological Analysis of A New Rat Model of Experimental Knee Osteoarthritis: C. Thomas G. Appleton, David D. McErlain, James L. Henry, David W. Holdsworth and Frank Beier.

18. Expression of MIG-6, WNT-7B and WNT-9A During Osteoarthritis: Cristina Velasquillo, David Garciadiego-Cazares, Maylin Almonte, Marcia Bustamante, Clemente Ibarra, Juan B. Kouri, Jesus Chimal-Monroy.

19. Calcitonin Affects Both Bone and Cartilage - A Possible Dual Action Tratment for Osteoarthritis?: Morten A. Karsdal, Bodil C. Sondergaard, Michel Arnold, Claus Christiansen.

Part III: Clinical and Therapeutic Challenges in Bone and Joint Disease:.

20. Progress, Paradox and Potential: Parathyroid Hormone (PTH) Research Over Five Decades: John T. Potts, and Thomas J. Gardella.

21. Bisphosphonates: From Bench to Bedside: Graham Russell.

22. Future Developments in Therapy: Carlos M. Isales and Jay M. McDonald.

23. Selecting Patients at Risk of Osteoporotic Fracture: The Proposed WHO risk platform: Stuart L. Silverman.

24. Progression of Efficacy With Ibandronate - A Paradigm For The Development of New Bisphosphonates: Mone Zaidi, Solomon Epstein, Steven T. Harris, Joseph D. Kohles,Charles H. Chesnut.

25. Rationale for Using Nitric Oxide Donor Therapay for Prevention of Bone Loss and Treatment of Osteoporosis in Humans: Sunil J. Wimalawansa.

26. Proteasome Inhibitors Stimulate both Bone Formation and Hair Growth by Similar Mechanisms: Gregory Mundy, Gloria Gutierrez, Ross Garrett, Wolfgang Gallwitz, Gianni Rossini, Claus Christiansen, and Andria Langenberg.

27. The Skeletal Dysplasias: Clinical-Molecular Correlations: David L. Rimoin, Daniel Cohn, Deborah Krakow, William Wilcox, Ralph S. Lachman, Yasemin Alanay.

28. Gene Therapy in Musculoskeletal Repair: Alan J. Nixon, Laurie R. Goodrich, Michael S. Scimeca, Tom H. Witte, Lauren V. Schnabel, Ashlee E. Watts, Paul D. Robbins.

29. Studies of Osteotropism on Both Sides of the Breast Cancer-Bone Interaction: Jodie Moreau, Kristen M. Anderson , Joshua R. Mauney, David Kaplan, and Michael Rosenblatt.

30. Effects of Adrenal Steroids on the Bone Metabolism of Children with Congenital Adrenal Hyperplasia: Karen Lin-Su and Maria I. New.

31. Quantitative Ultrasound Technology in Evaluating Bone Status and Osteoporosis in Patients with Cushing's Syndrome: Valentina Camozzi, Giovanni Luisetto, Monica Zangari, and Franco Lumachi.

32. Bone Mineral Density Improvement After Successful Parathyroidectomy in Pre- and Postmenopausal Women with Primary Hyperparathyroidism. A Prospective Study: Franco Lumachi, Valentina Camozzi,Mario Ermani, Frederica De Lotto, and Giovanni Luisetto.

33. Lumbar Spine Bone Mineral Density Changes in Patients with Primary Hyperparathyroidism According to Age and Gender: Franco Lumachi, Valentina Camozzi, Mario Ermani, Alfredo Nardi, and Giovanni Luisetto.

34. Osteogenic Differentiation of Human Mesenchymal Bone Marrow Cells in Silk Scaffolds is Regulated by Nitric Oxide: Petros D. Damoulis, Dimitrios E. Drakos, Eleni Gagari, David L. Kaplan.

35. IL-7 Modulats Osteoclastogenesis in Patients Affected by Solid Tumors: Ilaria Roato , Eva Gorassini, Giacomina Brunetti , Maria Grano, Libero Ciuffreda , Antonio Mussa and Riccardo Ferracini.

36. PTHrP and Tumorigenesis: Is There A Role in Prognosis?: Minoru Nishihara, Takashi Kanematsu, Mohammed S. Razzaque Takashi Taguchi