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Sickle Cell Disease and Hematopoietic Stem Cell Transplantation
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Main description:

This book provides a comprehensive, state-of-the art review of hematopoietic stem cell transplantation (HSCT) for sickle cell disease (SCD). The book reviews new data about risk prediction for severe SCD, outlines the unique challenges of HSCT for patients with SCD, profiles the supportive care guidelines for patients who are undergoing HSCT, highlights our current understanding of the best transfusion support for SCD patients prior to, during and after HSCT, and provides new perspectives about the ethics of HSCT for pediatric patients with SCD. Published in the last few years, several landmark phase III trials that utilize matched unrelated and haploidentical donors for HSCT in SCD patients are also placed in context with respect to current management. Written by experts in the field, Sickle Cell Disease and Hematopoietic Stem Cell Transplantation is a valuable resource for physicians and researchers dealing with and interested in this challenging, yet exciting, curative therapy for sickle cell disease, that will help guide patient management and stimulate investigative efforts.


Contents:

Part I Sickle Cell Disease

1. Clinical Manifestations of Sickle Cell Disease Across the Lifespan

Lydia H. Pecker, Jane Little

2. Pathobiology of Sickle Cell Disease Vaso-Occlusion and Targeted Therapies

Kerry A. Morrone, Jennifer Davila, W. Beau Mitchell, Deepa Manwani

3. Current Non-HSCT Related Treatments for SCD

Claire L. Anderson, Deepika S. Darbari

4. Risk Based Therapies for Sickle Cell Disease

Emily R. Meier

5. Transfusion Support of the Patient with Sickle Cell Disease Undergoing Transplantation

Jeanne E. Hendrickson, Ross M. Fasano

6. Neurological Manifestations of Sickle Cell Disease and Their Impact on Allogeneic Hematopoietic Stem Cell Transplantation

Jessica Carpenter, Monica L. Hulbert

Part II Hematopoietic Stem Cell Transplantation

7. Overview of Hematopoietic Stem Cell Transplantation for Non-Malignant Diseases

Karen L Zimowski, Shanmuganathan Chandrakasan

8. Unique Challenges of Hematopoietic Stem Cell Transplant for Sickle Cell Disease

Pooja Khandelwal, Michael Grimley

9. The Ethics of Hematopoietic Stem Cell Transplantation for Sickle Cell Disease

Robert Sheppard Nickel, Naynesh Kamani

10. Psychosocial Care and Education of Children with Sickle Cell Disease undergoing Hematopoietic Stem Cell Transplant and their Families

Steven J. Hardy, Jasmine Holt, Amanda L. Thompson

11. Long Term Effects of Hematopoietic Stem Cell Transplantation for Sickle Cell Disease

Karim T. Sadak, Angela R. Smith, Monica Bhatia

12. Matched Sibling Donor Hematopoietic Stem Cell Transplantation for Sickle Cell Disease

Gregory M.T. Guilcher, John T. Horan

13. Unrelated Donor Hematopoietic Stem Cell Transplantation for Sickle Cell Disease

Alexander Ngwube, Shalini Shenoy

14. Haploidentical Hematopoietic Cell Transplantation for Sickle Cell Disease

Elizabeth O. Stenger, Allistair Abraham15. Gene Therapy 101: The Path Toward Becoming a Realistic Cure for Patients with Sickle Cell Disease Alexis Leonard, Allistair Abraham


PRODUCT DETAILS

ISBN-13: 9783319623276
Publisher: Springer (Springer International Publishing AG)
Publication date: October, 2017
Pages: 457
Weight: 571g
Availability: Contact supplier
Subcategories: Haematology

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