Main description:

Exploring basic science and the clinical applications, Recurrent Pregnancy Loss: Causes, Controversies and Treatment provides an authoritative, comprehensive review of the management of recurrent pregnancy loss. Many subjects in this area are controversial, and occasionally clinical decisions are based on lack of knowledge rather than evidence. For this reason, chapters include debates by leading experts to aid the clinician in deciding on the appropriate clinical management.

Chapters cover basic science, genetics, and the application of evidence based medicine as well as mid- trimester loss, late obstetric complications, and related psychological mechanisms.

This book will be essential reading for specialists working in recurrent pregnancy loss clinics and associated disciplines, as well as anyone wishing to gain a comprehensive view of developments in the field.

Contents:

Epidemiology
Signaling between Embryo and Mother in Early Pregnancy
Genetics of Spontaneous Abortions
Debate: Should Fetal Karyotyping be performed in RPL? Debate: Should PGD be performed in RPL?
Opinion: Should CVS or Amniocentesis Be Performed in RPL without Screening
Does the Maternal Immune System Regulate the Embryo's Response to Teratogens?
Fetal Structural Malformations: Embryoscopy
Endocrinology
Debate: Should Progesterone Supplements Be Used? Debate: Should hCG Supplementation Be Used? Antiphospholipid Syndrome: Pathophysiology
Diagnosis of aPL-Associated Abortions
Management of Antiphospholipid Syndrome in Pregnancy
Defects in Coagulation Factors Leading to RPL
Debate: Should Thromboprophylaxis Be Used in Hereditary Thrombophilias with RPL?
Uterine Anomalies
Immunobiology
Debate: Should Immunotherapy Be Used in RPL? Infections
Midtrimester Loss: The Role of Cerclage
Midtrimester Loss and Viability
Obstetric Outcomes
Coping with RPL: Psychological Mechanisms
Methodological Issues in Evidence-Based Evaluation of Treatment
Investigation Protocol
A Patient's Perspective