Main description:

This second volume follows on from Part I by reviewing the variety of animal models of PD current available (from drosophila to rodents to non-human primate species) and their specific contributions to PD research. This is followed by comprehensive coverage of functional neuroimaging studies that explore different pathophysiological questions and evaluate treatment outcome in PD patients. Different areas of experimental therapeutics and outstanding challenges to PD treatment are presented in a concluding group of articles.

Contents:

Section I: Animal models of PD

What have we learned from Drosophila Models of Parkinson's Disease? - Ming Guo
Neurotoxic in vivo models of Parkinson's disease: recent advances - Timothy Greenamyre & Jason R. Cannon
Behavioural analysis of motor and non-motor symptoms in rodent models of Parkinson's disease - Stephen B. Dunnett & Mariah Lelos
Genetic mouse models of Parkinson's disease: the state of the art - Marie-Francoise Chesselet & Iddo Magen
Viral vector mediated overexpression of a-synuclein as a progressive model of Parkinson's disease - Anders Bjorklund, Ayse Ulusoy, Mickael Decressac, Deniz Kirik
Modelling inflammatory pathogenesis of Parkinson's Disease - Malu Tansey & Christopher J. Barnum
The MPTP-lesioned non-human primate models of Parkinson's disease. Past, present and future - Susan Fox & Jonathan Brotchie
Section II: Exploring PD with brain imaging

Abnormal Metabolic Brain Networks in Parkinson's Disease: From Blackboard to Bedside - David Eidelberg & Chris C. Tang
Imaging the Nigrostriatal System to Monitor Disease Progression and Treatment-Induced Complications - Jon Stoessl & Renju Kuriakose
Brain imaging after neural transplantation - Paola Piccini & Marios Politis
Imaging non-motor aspects of Parkinson's disease - David Brooks & Nicola Pavese
Section III: Frontiers in PD treatment

Gene therapy for dopamine replacement - Deniz Kirik & Tomas Bjoerklund, Erik Ahlm Cederfjall
Neurotrophic Factor Therapy for Parkinson's disease - Jeffrey Kordower, Rangasamy Suresh Babu, Katherine Soderstrom, Roy A.E. Bakay
Neural grafting in Parkinson's disease: Problems and possibilities - Patrik Brundin, Roger A Barker and Malin Parmar
Neural grafting in Parkinsons disease: Unraveling the mechanisms underlying graft-induced dyskinesia - Emma L Lane, Anders Bjoerklund, Stephen B Dunnett, Christian Winkler
Deep Brain Stimulation: State of the Art and Novel Stimulation Targets - Andres Lozano & Francisco A. Ponce
The challenge of Non-Motor Symptoms in Parkinsons Disease - Ray Chaudhuri & Per Odin