Main description:

This text properly considers the most recent and relevant advances in molecular RB of GB, taking into account the related topics of pathobiology, and underscores the most promising translational perspectives from the preclinical to the clinical domain. Section I (From Bedside to Bench) discusses conditions associated with RT resistance of GB and the consequent RB hints, technology improvements intended to overcome RT-resistance of GB, mathematical modeling of RB parameters from clinical studies, the present impact of molecular prognostic factors in therapy of GB, and RT tolerance of normal brain. Section II (Preclinical Research and Pathobiology Topics) presents the traditional and mechanistic/molecular approaches to RB of GB, genetic and epigenetic studies on GB, issues of cell-death pathways, stem-like cells, invasiveness, tumor microenvironment, hypoxia, mi-RNA manipulations, and nanoparticle technology. Section III (Translational Perspectives) presents RB issues related to molecular profiling and classification of GB as frames of reference for clinical studies, translational perspectives of gene therapy, evolving protocols based on pre-clinical data and large data-bases and ontologic models.

Radiobiology of Glioblastoma: Recent Advances and Related Pathobiology will be of great value to pathologists, medical oncologists, radiation oncologists as well as basic researchers and clinical investigators.

Contents:

1 Introduction and Background

Luigi Pirtoli, Giovanni Luca Gravina, Antonio Giordano

Part 1 From Bedside to Bench: Radiobiological Topics Arising from Clinical Studies

2 The "Radio-resistance of Glioblastoma in the Clinical Setting and the Present Therapeutic Options

Michela Buglione, Luca Triggiani, Paolo Borghetti, Sara Pedretti, Nadia Pasinetti, Stefano Maria Magrini

3 Radiobiological Hints from Clinical Studies

Silvia Scoccianti, Riccardo Santoni, Beatrice Detti, Gianluca Ingrosso, Daniela Greto, Giulio Francolini

4 Chemo-Radiotherapy: Radiation Total Dose and Fractionation

Silvia Chiesa, Mario Balducci, Milena Ferro, Anna Rita Alitto, Vincenzo Valentini

5 Clinical Evidence and Radiobiological Background of Particle Radiation Therapy<

Walter Tinganelli, Marco Durante

6 Mathematical Modelling of Radiobiological Parameters<

Piernicola Pedicini, Lidia Strigari, Luigi Spiazzi, Alba Fiorentino, Paolo Tini, and Luigi Pirtoli

7 Clinical, Pathological, and Molecular Prognostic Parametersin Glioblastoma Patients Undergoing Chemo- and Radiotherapy

Paolo Tini, Clelia Miracco, Marzia Toscano, Silvia Palumbo, Sergio Comincini, Giovanni Luca Gravina, and Luigi Pirtoli

8 Radiation tolerance of normal brain: QUANTEC 2010 and beyond.

Francesca De Felice, Vincenzo Tombolini, Michela Buglione , Daniela Musio, Luca Triggiani, and Stefano Maria Magrini

Part 2 Preclinical Research

9 Basic Knowledge of Glioblastoma Radiobiology

Monica Mangoni, Mariangela Sottili, Chiara Gerini, Lorenzo Livi

10 The Immune System and its Contribution to the Radiotherapeutic Response of Glioblastoma

Ralph Vatner, Encouse Golden, Joshua Silverman, Silvia Formenti

11 Genetic and epigenetic eterminants in tumor initiation and progression of glioblastoma.

A. Cimini, A. Fidoamore, M. D'Angelo,A. Antonosante, L. Cristiano, E. Benedetti, and Antonio Giordano

12 Tumor Microenvironment, Hypoxia, and Stem Cell-Related Radiation Resistance

Mariangela Sottili, Chiara Gerini, Isacco Desideri, Mauro Loi, Monica Mangoni, Lorenzo Livi

13 Cell Death Pathways, with Special Regard to Ionizing Radiation and Temozolomide

M Toscano, S Palumbo, P Tini, C Miracco, GL Gravina, S Comincini

14 miRNAManipulation in ModifyingRadiationSensitivity in Glioblastoma Models

S Palumbo; G Belmonte; P Tini; M Toscano; C Miracco; S Cominicini.

15 Nanomaterials Technology for Research Radiobiology

Elisa Panzarini, Luciana Dini

Part 3 From Bench to Bedside: Translational Perspectives

16 Pre-Clinical Models of Glioblastoma in Radiobiology: Evolving Protocols and Research Methods

Anita Tandle, Uma Shankavaram, Cody Schlaff, Kevin Camphausen,AndraKrauze

17 From Molecular to Clinical Radiation Biology of Glioblastoma

Nadia Pasinetti, Luigi Pirtoli, Michela Buglione, Luca Triggiani, Paolo Borghetti, Paolo Tini, and Stefano Maria Magrini

18 Perspective of the Large Databases and Ontologic Models of Correlation of Pre-Clinical and Clinical Results

Elisa Meldolesi , Mario Balducci, Silvia Chiesa, Andrea Damiani, Nicola Dinapoli, Roberto Gatta, and Vincenzo Valentini

19 Conclusive Remarks and Perspectives for Future Research

Antonio Giordano, Giovanni Luca Gravina, Luigi Pirtoli