Main description:

Once again, the proceedings of the Badgastein Symposium, this one being the 22nd in an uninterrupted series, offer a comprehensive record of the scientific events. Highlights at this meeting were certainly reports ofthe exciting new developments ofpositron imaging with Anger cameras, both with conventional high-energy collimators and with coincidence techniques. Preliminary c1inical results are promising and seem to offer a true alternative to sophisticated PET -technology with its for many laboratories prohibitive costs. The general nature ofthe symposium is documented by the large range oftopics covered so that all major topics of interest in both the basic sciences of nuc1ear medicine and c1inical ap- plication are found. In accordance with the general trends in nuc1ear medicine, there has been a substantial increase in oncological work compared to the more traditional topics. This is also reflected in the Badgastein lecture, given by Professor P. Rigo, who presented an excellent survey ofnuc1ear oncology.

Contents:

Clinical PET in Oncology.- Pretargeting: Improved Pharmacokinetics and Therapeutic Ratio.- Brain Tumors - Effect of Radiation Therapy on Amino Acid Transport.- Scintimammography with Technetium-99m-SESTAMIBI: Planar Scanning Vs. SPECT.- How to Further Evaluate Indeterminate Mammograms. A Comparison between Semiquantitative Tc-99m SESTAMIBI Scintimammography and Dynamic MRI.- The Use of Technetium-99m Methoxyisobutylisonitrile (Tc-99m-MIBI) Breast Scintigraphy For Early Detection of Breast Cancer.- FDG SPECTto Monitor Lung Cancer Chemotherapy.- Diagnosis and Therapy Control of Ocular Melanoma with 18-FDG-PET - A Pilot Study.- FDG-PET, I-131 and MIBI-Scintigraphy in the Follow-Up of Differentiated Thyroid Cancer.- 18-FDG/131-I-Alternating Uptake in Differentiated Thyroid Cancer - Whole Body PETin 41 Patients.- Tc-99m-SESTAMIBI Whole Body Scintigraphy: A Useful Tool in the Follow-Up of Patients with Differentiated Thyroid Carcinoma?.- Hurthle Cell Tumor and Technetium-99m-SESTAMIBI Scintigraphy (Single Injection Double-Phase Study).- Gallium and Magnetic Resonance Imaging in the Follow-Up of Mediastinal Lymphoma.- Lymphocytic Immunophenotypes in GMCSF-Associated Juxtaarticular Uptake on Bone Scintigraphy.- Neuroactivation and Vasoactivation Studies in Patients with Impaired Cognitive Function Using Tc-99m-HMPAO-SPECT.- Neuroactivation with SPECT and Smooth Pursuit Eye Movement in Schizophrenics.- Usefulness of Brain Perfusion SPET with Tc-99m ECD in High Risk Neonates.- Tc-99m-ECD Brain SPET in Diagnosis of Cerebral Perfusion Abnormalities in Children with Therapy-Resistant Epilepsy.- Striatal Dopamine Transporter in Parkinson's Disease Studied with [123-I]?-CIT-FP SPET.- Patterns of Different Brain SPECT Studies in Patients with Extrapyramidal Motor Symptoms (EPMS) and their Potential Impact on Clinical Management.- Impact of Somatostatin Receptor Scintigraphy in Patients with Suspected Meningeoma.- Bacterial Specific Infection Imaging.- In Vivo Detection of Activated Lymphocytes in Immune-mediated Diseases by 123-I-Interleukin-2 Scintigraphy.- Quantitative Evaluation of Myocardial Blood Flow and Coronary Reserve in Patients with Coronary Artery Disease: A Dobutamine Stress - [O-15] H2O-PET-Study.- Prediction of Improvement in Global and Regional Ventricular Function after Revascularization with FDG SPECT.- Myocardial Metabolism in Thyroid Dysfunctions Observed by Phosphorous-31 Spectroscopy.- Structural Alterations and the Effect of Coronary Revascularization on Myocardial Function in Regions with Moderate or Severe Persistent Thallium-201 Defects.- Imaging of Myocardial Amyloid Involvement with 99m-Tc-Aprotinin.- Thromboresistance is a Vascular Property.- Attenuation Correction in Cardiac SPET Using Two Gd-153 Line Sources - First Clinical Results.- 18-FDG Single Photon Emission Computed Tomography in Heart and Brain Scintigraphy - Instrumentation and Physical Aspects.- Iterative Reconstruction in PET Routine.- Quantitative Evaluation of Dynamic Renal Studies Using Fuzzy Regions of Interest and Functional Factor Images.- Ionisation Chamber Measurements of I-123 Using a Copper Filter.- The Separation of Church and State: How to Provide a Clean Interface Between Acquisition and Processing.- Colonic Transit in Lactulose and Polyethylene Glycol Induced Osmotic Diarrhea.- Clinical Value of Lung Perfusion Scintigraphy in Infants with Congenital Cardio-Pulmonary Disease.- Assessment of Mediastinal Involvement in Lung Cancer with [99m Tc]-SESTAMIBI SPET.- Bone Scanning in Preoperative Decision-Making in Hemimandibular Elongation.- Copper-67 Labeled mAb chCE7 as a Potential Therapeutic Agent for Neuroblastoma: Improved Biodistributions of Copper-67-chCE7 F(ab')2.- Final Evaluation of a Prospective Clinical Comparative Trial of 111-In-Labeled Polyclonal Human IGG (HIG) Scintigraphy vs. Ultrasonography in 100 Patients with Carotid Artery Disease.- Correlation on SPECT and CTImages in Brain Tumor Radioimmunotherapy.- Planar and SPECT Imaging in Thallium Myocardial Scintigraphy.- Radioimmunotherapy of CEA-Expressing Cancers: Clinical Results with an 131-I-Labeled Anti-CEA Monoclonal IgG1.- Advanced Prostate Cancer Therapy with Yttrium-90 Citrate.- Prostate Osseous Metastases: Evaluation of the Combined Application of Disodium Pamidronate/SR-89-Chloride/RE-186-HEDP.- Results of PET Dosimetry in the Treatment of Thyrotoxicosis by 131-I.- Radiopharmaceutical Development of 123-I-(+)-3-IODO-MK 801 for NMDA-Receptor Scintigraphy.- Simple Production of Yttrium-90 in a Chemical Form Suitable to Clinical Grade Radioconjugates.- Investigations into Biokinetics of I-123-Diethylstilbestrol Phosphate (DSEP) in Tumor-Bearing Mice.- Preoperative Thoracic Staging of Non-Small Cell Lung Cancer: 18-FDG-PET Evaluation.- Elevated Expression of Glucose Transporter Genes as Reason for an Increased F-18 FDG Uptake in Human Pancreatic Adenocarcinoma.- Biodistribution and Kinetics of 191-Pt in Patients Undergoing Therapy with Cisplatin.- Biodistribution Pharmacokinetics and Dosimetry of Tc-99m-D-Glucaric Acid in Humans.- Progress in Modelling of Biokinetics of 131-I.- Pharmacokinetics and Dosimetry after Combined Application of Sr-89-Chloride and Re-186-HEDP in Bone Metastases.- Rhenium-186 Labelled MAb-170: A Suitable Agent for Radioimmunotherapy of Ovarain Carcinoma?.- Beta-Gamma Dosimetry in Radioimmunotherapy: Examples of Model Calculation Applied to Brain Glioma and Comparison between Different Radionuclides.- Absorbed Dose Estimation by Combined Use of CT Information and Whole Body Scanning with a Dual Head Gamma Camera in Patients with Osteosarcoma Treated with 153-Sm-EDTMP.- Non-Immunogenic Hyperthyroidism Before and After Radioiodine Therapy: Cell Mass and Autonomous Function.- Artifacts in Reconstructed PET-Images Due to Variation in Detector Sensitivity.- Bremsstrahlung Planar and SPECT Imaging: Resolution and Contrast Analysis and Activity Quantitation.- Stannous Ion Determination: Importance and Relevance in Radiopharmaceutical Kits.- Feasibility of the Noninvasive Evaluation of Glucose Uptake in Skeletal Muscle Using F-18-Fluorodeoxyglucose and a Probe.- Pharmakokinetic Evaluation of Two Monoclonal Antibodies as Possible Immunoscintigraphy Agents for Pancreatic Cancer in Humans.- Preliminary Studies of Some 99m-Tc-Labeled Potential Myocardial Metabolic Agents in Rabbits.- Evaluation of Tumor Resistance Using Iodine-123 Labelled Anthracyclines in Cell Cultures.- Platelet Labeling with 67-Ga (67-Ga-Oxine, -Tropolone, -MPO).- Improved Synthesis and In Vitro Stability Test of Rhenium-188 Labeled Radiopharmaceuticals for Potential Use in Radiation Synovectomy.- Training in Radiopharmaceutical Quality Control.- Studies on Tumour Cell Targeting with Radiometals.- Regional Perfusion and Metabolism Before Revascularization Compared with Functional Outcome.- Coronary Artery Disease (CAD): ROC-Analysis of Tc-99m-MIBI-SPECT Versus Rb-82-PET.- Determination of the Myocardial Rubidium Extraction Fraction: Theoretical Investigation.- Comparison of Filtered Back Projection with Iterative Reconstruction in Tl-201 Scintigraphy.- Measurement of the Abdominal Retention of 75-Se-Homotaurocholic Acid (SeHCAT) in Patients with Diarrhoeic Syndromes.- Follow-Up of Cardiac Toxicity of Anthracycline Chemotherapy with Equilibrium Radionuclide Angiography.- Follow-Up of High-Dose Chemotherapy-Treated Patients with Bone Marrow Scintigraphy with 99m-Tc Nannocoll.- Quantitative Determination of Renal Tc-99m-MAG3, Clearance. A Comparison of Results Acquired Simultaneously in Whole Body Geometry and with a Gamma Camera in ROI-Technique.- Follow-Up of The Renal Scars in Asymptomatic Siblings of Children with Vesicoureteric Reflux.- Labeling of Antineuroblastoma Monoclonal Antibody (MoAb) and First Results of In-Vivo Distribution in Scid-Mice.- Relative Tc-99m-ECD Brain Uptake Under Baseline Conditions and After Acetazolamide.- Evaluation of Regional Cerebral Blood Flow in Patients with Major Depression Using HMPAO SPECT.- Ventilation Studies of the Middle Ear and the Paranasal Sinuses with Xenon-133.- Oxidative Stress and Free Radical Formation: Modification of Proteins and Their Glycosylated Products During Oxidative Conditions. Labeling of Age-Albumin with 125-Iodine.- Therapy Trials in Cancer Patients Using an Improved 3-Step Pretargeting Approach.- Course of Time and Extent of the Thyroid Volume Reduction After Radioiodine Therapy in Graves Disease and Autonomous Goitre.- Author Index.