Main description:

Preclinical Research in Down Syndrome: From Bench to Bedside, Volume 251, the latest release in the Progress in Brain Research series, highlights new advances in the field. Chapters in this updated release include Exploring genetic and epigenetic mechanisms underlying cognitive deficits in Dow syndrome, The trisomy paradox: gene expression dysregulation domains, the Influence of allelic differences in mouse models of Down syndrome, Modelling Down syndrome in cells: From stem cells to organoids, Modelling Down syndrome in animals from the early stage to the new generation of models, Mapping behavioral landscapes in Down syndrome animal models, and more.

Contents:

1. Genetic and epigenetic pathways in Down syndrome: Insights to the brain and immune system from humans and mouse models Y. Eugene Yu, Zhuo Xing, Catherine Do, Annie Pao, Eun Joon Lee, Sharon Krinsky-McHale, Wayne Silverman, Nicole Schupf and Benjamin Tycko 2. Influence of allelic differences in Down syndrome Randall J. Roper, Laura Hawley and Charles R. Goodlett 3. Modeling Down syndrome in cells: From stem cells to organoids Gillian Gough, Niamh L. O'Brien, Ivan Alic, Pollyanna A. Goh, Yeap Yee Jie, Jurgen Groet, Dean Nizetic and Aoife Murray 4. Modeling Down syndrome in animals from the early stage to the 4.0 models and next Maria del Mar Muniz Moreno, Veronique Brault, Marie-Christine Birling, Guillaume Pavlovic and Yann Herault 5. Mapping behavioral landscapes in Down syndrome animal models Maria Martinez de Lagran 6. Using mouse models to understand Alzheimer's disease mechanisms in the context of trisomy of chromosome 21 Claudia Cannavo, Justin Tosh, Elizabeth M.C. Fisher and Frances K. Wiseman 7. Focusing on cellular biomarkers: The endo-lysosomal pathway in Down syndrome Alexandra Botte and Marie-Claude Potier 8. Translational validity and implications of pharmacotherapies in preclinical models of Down syndrome Noemi Rueda, Jesus Florez, Mara Dierssen and Carmen Martinez-Cue 9. Plasticity as a therapeutic target for improving cognition and behavior in Down syndrome Carmen Martinez-Cue and Mara Dierssen