Main description:

This book discusses applications of pluripotent stem cells to study eye disease in vitro and to create novel therapies for degenerative eye diseases. Chapters are contributed by experts in the field and cover such topics as the use of pluripotent stem cells in 2D and 3D engineering of ocular tissues for disease modelling and drug testing as well as approaches to replace degenerated RPE and photoreceptors in macular degeneration and retinitis pigmentosa.

Pluripotent Stem Cells in Eye Disease Therapy presents a comprehensive discussion of basic science and clinical applications and is an indispensable resource for everyone from advanced graduate students to advanced professionals who want to learn about the potential of stem cell biology and its role in the field of retinal diseases.

Contents:

1. Pluripotent Stem Cells to Model Degenerative Retinal Diseases: The RPE perspective2. Utility of induced pluripotent stem cell-derived retinal pigment epithelium for an in vitro model of proliferative vitreoretinopathy3. Developing cell-based therapies for RPE-associated degenerative eye diseases4. Pluripotent Stem Cell derived 3D Ocular Tissue Transplantation - role of immune system in cell integration5. Use of Stem Cells to model optic nerve degeneration diseases 6. Surgical approaches for RPE/retina7. 3D Engineering Ocular Tissues for Disease Modeling and Drug TestingIndex