Main description:

This new edition offers a state-of-the-art and integrative vision of pharmacogenomics by exploring new concepts and practical methodologies focusing on disease treatments, from cancers to cardiovascular and neurodegenerative disorders and more. The collection of these theoretical and experimental approaches facilitates problem-solving by tackling the complexity of personalized drug discovery and development. Written by leading experts in their fields for the highly successful Methods in Molecular Biology series, the book aims to provide across-the-board resources to support the translation of pharmacogenomics into better individualized health care.
Authoritative and up-to-date, Pharmacogenomics in Drug Discovery and Development, Third Edition aims to aid researchers in approaching the challenges in pharmacogenomics and personalized medicine with the introduction of these novel ideas and cutting-edge methodologies.

Contents:

1. Target Discovery for Drug Development Using Mendelian Randomization

Daniel S. Evans

2. Human Leukocyte Antigen (HLA) Testing in Pharmacogenomics

Ann M. Moyer and Manish J. Gandhi

3. Pharmacogenomics in Targeted Therapy and Supportive Care Therapies for Cancer

Zahra Talebi, Alex Sparreboom, and Susan I. Colace

4. Pharmacogenomics in Cytotoxic Chemotherapy of Cancer

Zahra Talebi, Alex Sparreboom, and Susan I. Colace

5. Management of Side Effects in the Personalized Medicine Era: Chemotherapy-Induced Peripheral Neuropathy

Eleonora Pozzi and Paola Alberti

6. The Yin-Yang Dynamics in Cancer Pharmacogenomics and Personalized Medicine

Qing Yan

7. Design of Personalized Neoantigen RNA Vaccines Against Cancer Based on Next Generation Sequencing Data

Begona Alburquerque-Gonzalez, Maria Dolores Lopez-Abellan, Gines Luengo-Gil, Silvia Montoro-Garcia, and Pablo Conesa-Zamora

8. COVID-19 Pharmacotherapy: Drug Development, Repurposing of Drugs, and the Role of Pharmacogenomics

Rebecca Bock, Mariana Babayeva, and Zvi G. Loewy

9. Pharmacogenomics Informs Cardiovascular Pharmacotherapy

Mariana Babayeva, Brigitte Azzi, and Zvi G. Loewy

10. Pharmacogenomic Screening of Patient-Specific hiPSC-Derived Cardiomyocyte Drug Candidates Using High-Throughput Calcium Imaging

Malorie Blancard, K. Ashley Fetterman, and Paul W. Burridge

11. The Yin-Yang Dynamics in Cardiovascular Pharmacogenomics and Personalized Medicine

Qing Yan

12. GTPgS Assay for Measuring Agonist-Induced Desensitization of Two Human Polymorphic Alpha2B-Adrenoceptor Variants

Jordana I. Borges, Alexandra M. Carbone, Natalie Cora, Anastasiya Sizova, and Anastasios Lymperopoulos

13. Pharmacogenomics of Alzheimer's Disease: Novel Strategies for Drug Utilization and Development

Ramon Cacabelos, Vinogran Naidoo, Olaia Martinez-Iglesias, Lola Corzo, Natalia Cacabelos, Rocio Pego, and Juan C. Carril

14. Pharmacogenetics of Antipsychotic Treatment in Schizophrenia

Samar S.M. Elsheikh, Daniel J. Muller, and Jennie G. Pouget

15. The Pharmacogenetic Impact on the Pharmacokinetics of ADHD Medications

Jacob T. Brown

16. Pharmacogenetics of Addiction Therapy

David P. Graham, Mark J. Harding, and David A. Nielsen

17. Pharmacogenomics of Opioid Treatment for Pain Management

Sarahbeth Howes, Alexandra R. Cloutet, Jaeyeon Kweon, Taylor L. Powell, Daniel Raza, Elyse M. Cornett, and Alan D. Kaye

18. The Role of Pharmacogenomics in Postoperative Pain Management

E. Paylor Sachtleben, Kelsey Rooney, Hannah Haddad, Victoria L. Lassiegne, Megan Boudreaux, Elyse M. Cornett, and Alan D. Kaye

19. Pharmacogenetics of Drug Therapies in Rheumatoid Arthritis

Atinuke Aluko and Prabha Ranganathan

20. Pharmacogenomics in Children

Michael J. Rieder and Abdelbaset A. Elzagallaai

21. Genetic Ancestry Inference for Pharmacogenomics

I. King Jordan, Shivam Sharma, Shashwat Deepali Nagar, Augusto Valderrama-Aguirre, and Leonardo Marino-Ramirez