Main description:

Pathophysiology of Cardiovascular Disease has been divided into four sections that focus on heart dysfunction and its associated characteristics (hypertrophy, cardiomyopathy and failure); vascular dysfunction and disease; ischemic heart disease; and novel therapeutic interventions.
This volume is a compendium of different approaches to understanding cardiovascular disease and identifying the proteins, pathways and processes that impact it.

Contents:

Dedication: A Tribute to Dr. Horacio Cingolani. Preface. Acknowledgements.
I: Cellular Processes Involved in Heart Dysfunction. 1. Septic Cardiomyopathy; K. Werdan, et al. 2. Mitochondrial Function A Limiting Factor in Heart Failure? A.-M.L. Seymour. 3. Myosin Heavy Chain Isoforms Modulate Motor Function of Cardiac Myosin by Changing Crossbridge Kinetics; H. Yamashita, et al. 4. Role of Reactive Oxygen Species in the Regulation of Cardiac Myocyte Phenotype; M. Maytin, et al. 5. Functional Significance of Ryanodine Receptor-Mediated Calcium Leaks in Sarcoplasmic Reticulum Membranes; P. Rampersad, et al. 6. Cell-Cell and Cell-Extracellular Matrix Interactions in Cardiomyopathy; S. Onishi, et al. 7. Role of Phosphoinositide 3-Kinase Pathway on Cardiac Hypertrophy; T. Shioi, et al. 8. Role of Gas/GTPase and Calcium/Calmodulin-Dependent Protein Kinase II in the Signal Transduction Mechanisms Involved in Hyperthermic Preconditioning; I.F. Benter, et al. 9. Interactions of the Cyclic AMP and Nitric Oxide Pathways in Cardiac Fibroblasts; X.B. Gustavsson, L.L. Brunton. 10. Do Humoral and Mechanical Stimulation of Cardiomyocytes Share Common Induction Pathways? A. Pinson, R. Tirosh. 11. Differential Inhibition by the Phosphatase Inhibitor Cantharidin of the Anti-Adrenergic Effect of Endothelin-1 and Carbachol in the Canine Ventricular Myocardium; M. Endoh, et al. 12. Factors Involved in Self and Drug-Induced Spontaneous Ventricular Defibrillation: Intra and Inter Species Variations; M. Manoach, et al. 13. Cardiac ATP-Sensitive Potassium Channel: A Bi-Functional Channel/Enzyme Multimer; A.E. Alekseev, et al. 14. Measurement of Cytosolic pH Simultaneously with Isometric Tension in Canine Trabeculae; A. Guia, R. Bose.
II: Pathogenesis of Ischemic Heart Disease. 15. Redox Regulation of Ischemic Heart Disease; D.K. Das. 16. Cell Biology of Acute Reperfusion Injury; C. Schafer, H.-M. Piper. 17. Reactive Oxygen Species, Na+/H+ Exchange and Ca2+ Overload During Myocardial Ischemia/Reperfusion Injury: The Paradox Explained? E.C. Rothstein, P.A. Lucchesi. 18. Calcium Signaling during Acute Myocardial Ischemia: New Insights from Optical Mapping Techniques; W.T. Clusin. 19. Effects of Ischemia on Cardiomyocyte Connexin-43 Distribution and Phosphorylation Studied In Vivo and In Vitro Models; S. Tanguy, et al. 20. Temperature Dependence of Ischemic Preconditioning; J.S. Juggi, et al. Mechanism of Cardioprotective Effect of Remote Aortic Preconditioning; M. Singh, A. Sharma. 22. Inhibition of Degranulation of Resident Cardiac Mast Cells May Prevent Ischaemia and Reperfusion-Induced Myocardial Injury; M. Singh, H. Saini. 23. Mechanisms of Cardioprotection against Ischemia-Reperfusion Injury; R.B. Singh, N.S. Dhalla.
III: The Cellular Basis for Vascular Disease. 24. Modulation of Arachidonic Acid Metabolism by Phorbol 12-Mysristate 13-Acetate in Monocytes and Myocytes; Biao Lu, P.C. Choy. 25. Endothelium-Derived Hyperpolarizing Factor(s). Does it Exist and What Role Does it Play in the Regulation of Blood Flow? C.R. Triggle, et al. 26. Cytokinesis in Smooth Muscle; N.L. Stephens. 27. ADP-Ribosylation and the Cardiovascular System;