Main description:

In recent years, considerable advances have been made in our knowledge and understanding of Parkinson's disease (PD). In particular, there has been an explosion of information regarding genetic contributions to the etiology of PD and an increased awareness of the importance of the non-motor features of the disease. Theories regarding the pathogenesis and pathophysiology of PD have also been refined, and new treatment modalities and advances implemented. Reflecting these changes, this second edition features new chapters devoted to genetic aspects of PD, non-motor features of the disease, and aspects of the pathophysiology, pathogenesis, and treatment of PD.

Contents:

Overview
James Parkinson
Jennifer G. Goldman and Christopher G. Goetz
Parkinson’s Disease: Where Have We Been?
Lawrence W. Elmer
Parkinson’s Disease: Where Are We?
Raúl de la Fuente-Fernández

Epidemiology
Epidemiology of Parkinson’s Disease: An Overview
Monica Korell and Caroline M. Tanner
Environmental Toxins and Parkinson’s Disease
Jason R. Cannon and Timothy J. Greenamyre
Rural Environment and Parkinson’s Disease
Daniel Strickland
Industrial and Occupational Exposures and Parkinson Disease
Samuel Goldman
Tetrahydroisoquinolines and Parkinson’s Disease
Mark S. LeDoux
Endogenous Neurotoxins in the Pathogenesis and Progression of Parkinson’s Disease
Shaik Shavali and Manuchair Ebadi

Genetics
Overview of the Genetics of Parkinsonism
Mathias Toft and Zbigniew K. Wszolek
α-Synuclein and Parkinson’s Disease
Thomas Gasser
LRRK2-Associated Parkinson’s Disease
Jonathan Carr and Soraya BardienParkin-Associated Parkinson’s Disease
Anne Grünewald and Christine KleinPINK1- and DJ-1-Linked Parkinsonism
Eng-King Tan
Genetic and Bioinformatic Tools in Parkinson’s Disease
Tatiana Foroud and Nathan Pankratz

Clinical Features of Parkinson’s Disease
Tremor, Rigidity, and Bradykinesia
Kelvin L. Chou and Howard I. Hurtig
Gait Disorders in Parkinson’s Disease
Yacov Balash, Jeffrey M. Hausdorff, Tanya Gurevich, and Nir Giladi
Somesthesia
Padraig O’Suilleabhain
Pain in Parkinson’s Disease
Blair Ford
Restless Legs Syndrome and Periodic Limb Movements of Sleep
Bryan T. Klassen and Charles H. Adler
Fatigue: A Common Comorbidity in Parkinson’s Disease
Anelyssa D’Abreu and Joseph H. Friedman
Visual Dysfunction in Parkinson’s Disease
Robert L. Rodnitzky
Visuo-Cognitive Dysfunctions in Parkinson’s Disease
Andrea Antal, Walter Paulus, and Ivan Bodis-Wollner
Olfactory Dysfunction in Parkinson’s Disease and Parkinsonian Syndromes
Katerina Markopoulou and Bruce A. Chase
Insomnia and Excessive Daytime Sleepiness in Parkinson’s Disease
J.A. Van Gerpen and Pablo Castillo
REM Sleep Behavior Disorder
Aleksandar Videnovic and Cynthia L. Comella
Gastrointestinal Dysfunction in Parkinson’s Disease
Ronald F. Pfeiffer
Urological Dysfunction
Carlos Singer and Henry Moore
Sexual Dysfunction
Cheryl Waters and Janice Smolowitz
Cardiovascular Autonomic Dysfunction in Parkinson’s Disease and Parkinsonian Syndromes
Valeria Iodice, David Low, Ekawat Vichayanrat, and Christopher J. Mathias
Disorders of Thermoregulation in Parkinson’s Disease
Thomas L. Davis
Respiratory Dysfunction
Holly Shill
Depression in Parkinson’s Disease
Steven P. Wengel, Dennis P. McNeilly, and William J. Burke
Anxiety and Parkinson Disease
Jeremy Quickfall, Michael Trew, and Oksana Suchowersky
Apathy in Parkinson’s Disease
Howard D. Weiss and Laura Marsh
Dementia
Anne L. Barba, B. Kelly Changizi, Donald S. Higgins, Stewart A. Factor, and Eric S. Molho

Pathophysiology of Parkinson’s Disease
Animal Models of Basal Ganglia Injury and Degeneration and Their Application to Parkinson’s Disease Research
Giselle M. Petzinger and Michael W. Jakowec
Neuroanatomy of Parkinson’s Disease
Heiko Braak and Kelly Del Tredici-Braak
Neuropathology of Parkinson’s Disease
John E. Duda and Dennis W. Dickson
Neurophysiology of the Motor Disorder in Parkinson’s Disease
Gaëtan Garraux and Mark Hallett
Neurochemistry of Parkinson’s Disease: Dopamine
L. Charles Murrin
Pathophysiology of Parkinson’s Disease, Neurochemical Pathology: Other Neurotransmitters
Yoshikuni Mizuno

Theories of Pathogenesis
Oxidative Stress
Casey Cook and Leonard Petrucelli
Mitochondrial Dysfunction
Daniel G. Healy and A.H.V. Schapira
Excitotoxicity
Fabio Blandini
Inflammation
Roger Kurlan
Protein Conformational and Metabolic Changes in Parkinson’s Disease
Kevin St. P. McNaught and C. Warren Olanow
Cell Death in Parkinson’s Disease
Shankar Sadasivan, Ané Korff, Ciaran J. Faherty, and Richard Jay Smeyne

Diagnosis of Parkinson’s Disease
Differential Diagnosis of Parkinson’s Disease
Serena W. Hung and Anthony E. Lang
Neuroleptic-Induced Movement Disorders
Manuchair Ebadi
Clinical Diagnostic Criteria for Parkinson’s Disease
Daniel Tarsy and Laurie Gordon
Clinical Batteries and Biomarkers in the Diagnosis of Parkinson’s Disease
Claire Henchcliffe and Un Kang
Rating Scales
Kathleen M. Shannon
MR Imaging of Parkinsonism
James B. Wood
Molecular Imaging in Parkinson Disease
Danna Jennings, David Russell, Ken Marek, and John Seibyl
Positron Emission Tomography in Parkinson’s Disease
Silke Appel-Cresswell, R. Nandhagopal, John R. Adams, and A. Jon Stoessl
Transcranial Ultrasound in Parkinson’s Disease
Daniela Berg, Bettina Faust, and Alexandra Gaenslen
In Vivo Molecular Imaging in Parkinson’s Disease
Sushil K. Sharma and Manuchair Ebadi
Placebo Effect in Parkinson’s Disease
Jayasri Srinivasan, Sarah C. Lidstone, Raúl de la Fuente-Fernández, and A. Jon Stoessl
Treatment of Parkinson’s Disease with Anticholinergic Medications
Duarte Machado and Bahman Jabbari
Amantadine
Kelly E. Lyons and Rajesh Pahwa
MAO-B Inhibitors for the Treatment of Parkinson’s Disease
John Bertoni
Catechol-O-Methyltransferase Inhibitors in the Treatment of Parkinson’s Disease
Mervat Wahba, Theresa A. Zesiewicz, and Robert A. Hauser
Symptomatic Treatment of Parkinson’s Disease: Levodopa
John L. Goudreau and J. Eric Ahlskog
Dopamine Agonists in Parkinson’s Disease
Joseph Jankovic and Toby C. Yaltho
Non-Dopaminergic Drugs for Motor Symptoms
Pierre R. Burkhard and Francois J.G. Vingerhoets
Stereotactic Ablative Procedures for Intractable Parkinson’s Disease
Marco Sassi and Michael S. Okun
Deep Brain Stimulation Surgery
Ryan J. Uitti, Yashiko Baba, and Robert E. Wharen Jr.
Neurotransplantation in the Treatment of Parkinson’s Disease
Penelope Hallett and Ole Isacson
Role of Physical Therapy in Management of Parkinson’s Disease
Rose Wichmann
Speech Therapy in the Treatment of Parkinson’s Disease
Shimon Sapir, Lorraine Ramig, and Cynthia Fox
Dysphagia in Parkinson’s Disease
Lisa A. Newman
Restorative and Functional Occupational Therapy in Parkinson’s Disease
Surya Shah
Neurologic Music Therapy: A Modality to Address the Diverse Needs of People with Parkinson’s Disease
Sandra L. Holten
Dance for Persons with Parkinson’s Disease*
Olie Westheimer
Pathogenesis of Motor Response Complications in Parkinson’s Disease: "Mere Conjectural Suggestions" and Beyond
Leo Verhagen Metman and Christina L. Vaughan
Treatment of Early Parkinson’s Disease
John C. Morgan and Kapil D. Sethi
Treatment of Moderate Parkinson’s Disease
John E. Duda and Matthew B. Stern
Management of Advanced Parkinson’s Disease
Grace S. Lin Liang and James W. Tetrud
Role and Design of Clinical Trials for Parkinson’s Disease
Andrew Siderowf and Stanley Fahn
Future Symptomatic Therapy in Parkinson’s Disease
Ruth Djaldetti, Shlomit Yust-Katz, and Eldad Melamed
Calcium Influx, Free Radicals, and Aging: A Metabolic Burden Linked to Neuronal Loss in Parkinson’s Disease
Javier Sanchez-Padilla, Jaime N. Guzman, and D. James Surmeier
Therapeutic Potential of Exercise in Parkinson’s Disease
Brian K. Schilling
Gene Therapy for Parkinson’s: Disease from Bench to Bedside
Fredric P. Manfredsson, Aaron C. Rising, M. Angela Cenci, Carmen S. Peden, and Ronald J. Mandel
Translating Stem Cell Biology to Regenerative Medicine for Parkinson’s Disease
Florian A. Siebzehnrubl and Dennis A. Steindler
Alternative Drug Delivery in the Treatment of Parkinson’s Disease
Pierre J. Blanchet
Economics of Parkinson’s Disease
Jessica Mastalski, Robert G. Holloway, and Katia Noyes
Informal Caregiving: An Essential Part of the Team
Carmen Dyck and Susan M. Calne
Driving in Parkinson’s Disease
Ergun Y. Uc
Evolution and Potential of the National Parkinson’s Organizations: A Brief Overview
Ruth A. Hagestuen
Comprehensive Parkinson’s Disease Care in Complex Environments
Elaine Cohen, Monique Giroux, Ruth A. Hagestuen, and Gladys Gonzalez-Ramos
Index