Main description:

Organofluorine Compounds in Biology and Medicine covers topics on biochemically relevant organofluorine compounds and their synthesis and biochemical pathways. Organofluorine compounds have renewed interest in pharmaceutical industry, and therefore a concise book on this topic is highly relevant to the scientific community involved in this area.

Contents:

1. Introduction: General aspects of organofluorine compounds 2. C-F bond strengths 3. Effect of the neighboring C-F bonds on the C-H bond dissociation energies 4. Effect of fluorine on the acidity and basicity 5. Effect of fluorine on the metabolic stability 6. Effect of fluorine on the bioavailability 7. Positron emission tomography (PET) tracers 8. 19F NMR Spectroscopic techniques for probing biochemical mechanisms 9. Summary and outlook