Main description:

Leading authors review the state-of-the-art in their field of investigation, and provide their views and perspectives for future research. Chapters are extensively referenced to provide readers with a comprehensive list of resources on the topics covered. All chapters include comprehensive background information and are written in a clear form that is also accessible to the non-specialist.

Contents:

Many Faces of Orexin/Hypocretin
Anantha Shekhar

Overview of Orexin/Hypocretin System
Michihiro Mieda and Takeshi Sakurai

Hypocretins and the Neurobiology of Sleep-Wake Mechanisms
Luis de Lecea

Respiration and Autonomic Regulation and Orexin
Eugene Nattie and Aihua Li

Orexins, Feeding and Energy Balance
Elodie Girault, Chun-Xia Yi, Eric Fliers and Andries Kalsbeek

Orexin and Natural Reward: Feeding, Maternal and Male Sexual Behavior
Andrea R. Di Sebastiano and Lique M. Coolen

Multiple Roles for Orexin/Hypocretin in Addiction
Stephen V. Mahler, Rachel J. Smith, David E. Moorman, Gregory S. Sartor and Gary Aston-Jones

Hypocretin Modulation of Drug-Induced Synaptic Plasticity
Corey Baimel and Stephanie L. Borgland

Orexin, Stress and Anxiety/Panic States
Philip L. Johnson Andrei Molosh, Stephanie D. Fitz, William A. Truitt and Anantha Shekhar

Orexin Receptors as Therapeutic Drug Targets Anthony L. Gotter, Anthony J. Roecker, Richard Hargreaves, Paul J. Coleman, Christopher J. Winrow and John J. Renger