Main description:

This Annals volume presents a series of short reviews stemming from the 2012 3rd International Conference on Nutrition and Physical Activity (NAPA) in Aging, Obesity, and Cancer. The papers focus on advances in, and future directions for, physical and nutritional bio-modulation and prevention of aging, obesity, and cancer. NOTE: Annals volumes are available for sale as individual books or as a journal. For information on institutional journal subscriptions, please visit: http://ordering.onlinelibrary.wiley.com/subs.asp?ref=1749-6632&doi=10.111/(ISSN)1749-6632 ACADEMY MEMBERS: Please contact the New York Academy of Sciences directly to place your order (ww.nyas.org). Members of the New York Academy of Sciences received full-text access to Annals online and discounts on print volumes. Please visit http://www.nyas.org/MemberCenter/Join.aspx for more information on becoming a member.

Contents:

Cancer prevention as biomodulation: targeting the initiating stimulus and secondary adaptations 1 Priscilla A. Furth Janus-faced role of SIRT1 in tumorigenesis 10 Na-Young Song and Young-Joon Surh Unfolded protein response to autophagy as a promising druggable target for anticancer therapy 20 Dong Hoon Suh, Mi-Kyung Kim, Hee Seung Kim, Hyun Hoon Chung and Yong Sang Song Genomics of complex traits 33 James E. Womack, Hyun-Jin Jang, and Mi Ok Lee Obesity and cancer risk: evidence, mechanisms, and recommendations 37 Ivana Vucenik and Joseph P. Stains Molecular mechanisms of garlic-derived allyl sulfides in the inhibition of skin cancer progression 44 Hsiao-Chi Wang, Jung Pao, Shuw-Yuan Lin, and Lee-Yan Sheen Molecular function of macrophage migration inhibitory factor and a novel therapy for inflammatory bowel disease 53 Jun Nishihira Molecular determinants of ovarian cancer chemoresistance: new insights into an old conundrum 58 Ahmed Y. Ali, Lee Farrand, Ji Young Kim, Sanguine Byun, Jeong-Yong Suh, Hyong Joo Lee and Benhamin K. Tsang Inositol polyphosphate multikinase signaling in the regulation of metabolism 68 Joo-Young Lee, Young-ran Kim, Jina Park, and Seyun Kim Cutaneous responses to environmental stressors 75 Giuseppe Valacchi, Claudia Sticozzi, Alessandra Pecorelli, Franco Cervellati, Carlo Cervellati, and Emanuela Maioli Obesity, metabolic dysregulation, and cancer: a growing concern and an inflammatory (and microenvironmental) issue 82 Stephen D. Hursting and Sarah M. Dunlap Select nutrients, progesterone, and interferon tau affect conceptus metabolism and development 88 Fuller W. Bazer, Jingyoung Kim, Gwonhwa Song, Hakhyun Ka, Carmen D. Tekwe, and Guoyao Wu Diversification and conservation of the extraembryonic tissues in mediating nutrient uptake during amniote development 97 Guojun Sheng and Ann C. Foley Genetic modification of chicken germ cells 104 Tae Sub Park and Jae Yong Han Role of PGC-1 signaling in skeletal muscle health and disease 110 Chounghun Kang and Li Li Ji MicroRNA-target interactions: new insights from genome-wide approaches 118 Dooyoung Lee and Chanseok Shin