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Main description:
After theend ofthe 20th century, the science ofcrystallizationreached a truly exciting stage where new opportunities emerged in both theory and expe- ment. Variousphysical methodsare capableofresolvingthesurface as wellas theinsidestructureofcrystalsattheatomiclevelwhilenewhigh-performance computingresourcesaffordthecapabilityofmodelingthecomplexlarge-scale alignmentsnecessarytosimulatecrystallizationinrealsystems.Asaresult,the science of crystallization has shifted gradually fromstatic to dynamic science and considerable progress now underlies the complex but beautiful cryst- lization process. I believe that if a de?nitive history of 21st century science is ever written,one of the highlightswill be the science ofcrystallization. This science has the following characteristics: in?nite advances in soph- tication, unlimited opportunities not only for intellectual excitement but also forindustrialmerit,strongcollaborationwithbiologyandmaterialscience,as wellaswithallareasofchemistry.Thevastpotentialofcrystallizationasan- portant?eld ofscience isfar beyondthesimple technologyofpharmaceutical industries during the 20th century.
Optical resolution was one small area of chemistry in the last century. This was more a technology than a science, largely because trial and error was the only method to obtain good results. However, the situation is now changing. Therearesomanyappealing,hidden?ndingsintheprocessofcrystallization. Historically, crystallization began in an old laboratory in academia and then gradually shifted to industry. Now,it is making itscomeback in academia due toseveralnewresearchbranchestryingtodiscoverwhatisgoingonduringthe crystallizationprocess.Ibelieve this?eld ofscience isnowgrowingasa result of the wonderfulcoupling between industry and academia. I read a prepublication draft of Novel Optical Resolution Technologies,and foundthateachoneofthesegeneralcharacteristicsofsciencehadarealityand sharpness that I had not expected. While it was a sheer delight to revisit each of these triumphs guided by the wise insights and analyses found throughout the book. There is a good balance between the underlying historical material and the design and execution aspects of each topic.
Contents:
G. Coquerel: Preferential Crystallization.- R. Tamura, H. Takahashi, D. Fujimoto, T. Ushio: Mechanism and Scope of Preferential Enrichment, a Symmetry-Breaking Enantiomeric Resolution Phenomenon.- R. Yoshioka: Racemization, Optical Resolution, and Crystallization-Induced Asymmetric Transformation of Amino Acids and Pharmaceutical Intermediates.- F. Faigl, J. Schindler, E. Fogassy: Advantages of Structural Similarities of the Reactants in Optical Resolution Processes.- R.M. Kellogg , B. Kaptein, T.R. Vries: Dutch Resolution of Racemates and the Roles of Solid Solution Formation and Nucleation Inhibition.- K. Sakai, R. Sakurai, H. Nohira: New Resolution Technologies Controlled by Chiral Discrimination Mechanisms.- K. Sakai, R. Sakurai, N. Hirayama: Molecular Mechanisms of Dielectrically Controlled Resolution (DCR).- H. Murakami: From Racemates to Single Enantiomers - Chiral Synthetic Drugs over the Recent 20 Years
PRODUCT DETAILS
Publisher: Springer (Springer-Verlag Berlin and Heidelberg GmbH & Co. K)
Publication date: November, 2010
Pages: 328
Weight: 504g
Availability: Available
Subcategories: Biochemistry
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