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MORE ABOUT THIS BOOK
Main description:
In the last 50 years molecular biology was dominated by the exploration of proteins and nucleic acids. Beside their role in energy metabolism, oligos- charides,which represent thethirdclass ofbiomacromolecules, have received less attention. Today it is well established that oligosaccharides are involved in many important biologicalregulation and recognition processes fromp- tein folding to cell-cell communication. Glycosylation of proteins is the most complexformofco-andposttranslationalmodi?cation. Thedeterminationof structure-function relationships, however, remains dif?cult due to the mic- heterogeneity of glycoproteins that exist in many different glycoforms. Thus chemical synthesis of glycoproteins and glycopeptides with de?ned glycan structures plays a pivotal role for the detailed determination of the role of protein glycosylation. This topic is covered by the ?rst two chapters of this bookdealingwiththechemicaland enzymatic synthesis ofglycopeptides and glycoproteins. The third chapter describes the construction of glycopeptide andglycoproteinmimetics containingnon-naturalstructuralelements.
These so-calledneoglycopeptidesandneoglycoproteins,respectively,canprovide- sight on the importance of distinct structural elements on biological activity andmayhaveimproved propertiessuchasanincreased stability. Theappli- tion of synthetic glycopeptides, in many cases at the clinical level, as vaccines forbothcancerandHIVisthesubjectofthefourthchapter. Glycopeptide antibiotics are glycosylated secondary metabolites of bacteria and fungi that are synthesized by non-ribosomal peptide synthetases. Some of them serve as antibiotics of last resort in the treatment of nosocomial infections with enterococci and methicillin-resistant Staphylococcus aureus (MRSA) strains. Their structure, biosynthesis, and mode of action are summarized in the ?fth chapter. The last chapter covers current methods for the determination of high-resolution structures of glycopeptides and glycoproteins mainly based onNMRspectroscopy, X-raycrystallography,and molecular modeling.
Contents:
C. Haase, O. Seitz: Chemical Synthesis of Glycopeptides.- D.A. Thayer, C.-H. Wong: Enzymatic Synthesis of Glycopeptides and Glycoproteins.- D. Specker, V. Wittmann: Synthesis and Application of Glycopeptide and Glycoprotein Mimetics.- J.D. Warren, X. Geng, S.J. Danishefsky: Synthetic Glycopeptide-Based Vaccines.- F. Wolter, S. Schoof, R.D. Sussmuth: Synopsis of Structural, Biosynthetic, and Chemical Aspects of Glycopeptide Antibiotics.- B. Meyer, H. Moeller: Conformation of Glycopeptides and Glycoproteins
PRODUCT DETAILS
Publisher: Springer (Springer-Verlag Berlin and Heidelberg GmbH & Co. K)
Publication date: November, 2010
Pages: 280
Weight: 433g
Availability: Available
Subcategories: Biochemistry
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