Main description:

Nitric Oxide in Health and Disease: Therapeutic Applications in Cancer and Inflammatory Disorders presents updated information on the chemistry, signaling of newly derived therapeutic nitric oxide donors/inhibitors, and their complexes in liposomes or nanospheres in both pre-clinical and clinical activities. The book discusses many examples of research related to the application of novel therapeutic compounds that focus on a chemical-nitric oxide-and its applications that have been shown to exert significant therapeutic activities against various resistant cancers unresponsive to current treatments and different inflammatory diseases which continue to require novel treatments.

This is a valuable resource for cancer researchers, oncologists, graduate students and researchers from medical and biomedical fields who want to know more about NO and its therapeutic applications in cancer and inflammatory diseases.

Contents:

Section 1: General properties of NO/metabolites in human diseases
Section 2: Development of novel NO donors/inhibitors and NO complexes: properties, cell signaling, synergy
Section 3: Pharmacokinetics of NO donors/inhibitors in animal models and toxicities
Section 4: Red-Ox signaling and modification of proteins. Characterization of their modified functions
Section 5: Therapeutic applications of NO donors/inhibitors in non-cancer related human diseases
Section 6: Therapeutic applications of NO donors/inhibitors in various cancers
Concluding remarks and future perspectives