Main description:

In this thoroughly updated and revised edition of his much praised book, Paul L. Wood and a panel of leading researchers capture these new developments in a masterful synthesis of what is known today about the inflammatory mediators and cells involved in neurodegenerative diseases. This second edition contains extensive updates on the mediators produced by microglia and their role in neuroinflammatory-induced neuronal lysis. There is also increased coverage of the animal models used in the study of neuroinflammatory mechanisms, of the new imaging methods that allow the noninvasive evaluation of microglial activation in human neurodegernerative disorders, and of the role of neuroinflammation in amyloid-dependent neuronal lysis.

Contents:

I. Neuroinflammatory Mechanisms

Microglia: Roles of Microglia in Chronic Neurodegenerative Diseases
Paul L. Wood

Apoptosis vs Nonapoptotic Mechanisms in Neurodegeneration
Kurt A. Jellinger

Role(s) of Mitogen and Stress-Activated Kinases in Neurodegeneration
Christopher C. J. Miller, Steven Ackerley, Janet Brownlees, Andrew J. Grierson, and Paul Thornhill

Roles of Chemokines and Their Receptors in Neuroinflammation
Andrzej R. Glabinski and Richard M. Ransohoff

Neurotoxic Mechanisms of Nitric Oxide
Kathleen M. K. Boje

Chronic Intracerebral LPS as a Model of Neuroinflammation
Gary L. Wenk and Beatrice Hauss-Wegrzyniak

Peroxisome Proliferator-Activated Receptor Gamma Agonists: Potential Therapeutic Agents for Neuroinflammation
Gary E. Landreth, Sophia Sundararajan, and Michael T. Heneka

Neuroinflammation-Mediated Neurotoxin Production in Neurodegenerative Diseases: Potential of Nitrones as Therapeutics
Robert A. Floyd and Kenneth Hensley

II. Stroke and TBI

Inflammation and Potential Anti-Inflammatory Approaches in Stroke
Jari Koistinaho and Juha Yrjanheikki

Neuroinflammation as an Important Pathogenic Mechanism in Spinal Cord Injury
Yuji Taoka and Kenji Okajima

Type IV Collagenases and Blood-Brain Barrier Breakdown in Brain Ischemia
Yvan Gasche, Jean-Christophe Copin, and Pak H. Chan

III. Alzheimer's Disease

Neuroinflammatory Environments Promote Amyloid-b Deposition and Posttranslational Modification
Craig S. Atwood, Mark A. Smith, Ralph N. Martins, Rudolph E. Tanzi, Alex E. Roher, Ashley I. Bush, and George Perry

Microglial Responses in Alzheimer's Disease: Recent Studies in Transgenic Mice and Alzheimer's Disease Brains
Douglas G. Walker and Lih-Fen Lue

The Amyloid Hypothesis of Cognitive Dysfunction
Dave Morgan and MarciaN. Gordon

The Cerebellum in AD: A Case for Arrested Neuroinflammation?
Paul L. Wood

The Neuroinflammatory Components of the Trimethyltin (TMT) Model of Hippocampal Neurodegeneration
G. Jean Harry and Christian Lefebvre d'Hellencourt

Inflammation and Cyclo-Oxygenase in Alzheimer's Disease: Experimental Approaches and Therapeutic Implications
Patrick Pompl, Tara Brennan, Lap Ho, and Giulio Maria Pasinetti

IV. Multiple Sclerosis

Experimental Autoimmune Encephalomyelitis
Hans-Peter Hartung and Bernd C. Kieseier

Neuroimmunologic Mechanisms in the Etiology of Multiple Sclerosis
Claudia F. Lucchinetti, W. Bruck, and Hans Lassmann

In Vivo Imaging of Neuroinflammation in Neurodegenerative Diseases
Annachiara Cagnin, Alexander Gerhard, and Richard B. Banati

V. Parkinson's and Huntington's Diseases

Inflammatory Mechanisms in Parkinson's Disease
Joseph Rogers and Carl J. Kovelowski

Neuroinflammatory Components of the 3-Nitropropionic Acid Model of Striatal Neurodegeneration
Hideki Hida, Hiroko Baba, and Hitoo Nishino

Index