Main description:

Data of all relevant aspects of neuronal cell growth and differentiation are presented in this volume. Regulation of expression, storage and release of nerve growth factors, receptor control and the cellular responses to growth factors are comprehensively discussed. Treated are also influences of various neurotransmitters on neuronal morphogenesis and new results of interactions of cells and mediators of the immune, endocrine and nervous system. Special emphasis is given to those factors regulating regeneration and nerve spreading after injuries of the nerve tissue.

Contents:

Theme I: Growth Factors and Hormones in Development and Aging of Neurons and Glia.- Developmental Biology of the Optic Nerve.- Neural Crest Cells Change Their Homing Behavior Following Treatment With a Phorbol Ester Drug.- Differentiation of Glial Precursors in Cerebellar Primary Cultures.- Neuroectodermal Cells: Storage and Release of Growth Factors.- Acetyl-L-Carnitine in the Rat's Hippocampus Aging: Morphological, Endocrine and Behavioral Correlates.- Glia-Promoting Factors and the Control of Oligodendroglial Growth During Brain Development and Regeneration.- Cholinergic Neurons of the Rat Forebrain in Slice Cultures; Interactions with Target Tissue and Effects of Nerve Growth Factor.- Nerve Growth Factor Effects on CNS Cholinergic Neurons In Vivo.- Expression of NGF Receptors During Development of Central Sensory Pathways in the Rat.- Rate Limiting Events in Neurite Outgrowth.- Studies of the Neurotransmitter Plasticity of Cultured Rat Sympathetic Neurons at the Molecular Level.- Serotonin and Morphogenesis in the Cultured Mouse Embryo.- Gaba and Taurine as Signals for Neuronal Development and Differentiation.- Adaptive Changes in an Animal Model of Micro-Encephaly.- Theme II: Mechanisms of Gene Expression.- Cell Fate and Gene Expression in the Developing Neural Crest.- Transiently Induced Sequences as Potential Mediators of Cellular Proliferation and Differentiation.- Expression of the C-SRC Proto-Oncogene Product in Neural Cells.- Induction of the 68/72 kDa Heat-Shock Protein During Hydrogen Peroxide Toxicity.- Developmental Expression of Nerve Growth Factor.- Structure and Expression of B-Nerve Growth Factor in the Rat Central Nervous System.- Molecular Aspects of the Rat Nerve Growth Factor Receptor.- Regulation of the Synthesis of Nerve Growth Factor and Nerve Growth Factor Receptor.- Regulation of Gene Expression in Nerve Cells: Effect of Growth and Trophic Factors.- Developmental Aspects of Myelin Membrane Protein Synthesis: Spatial Segregation of Polyribosomes.- Cytotypic Specialization of the Neuronal Cytoskeleton and the Cytomatrix: Implications for Neuronal Growth and Regeneration.- A cDNA Coding For Rabbit Neurofilament Protein H: A Window on the Role of H in Neurodegenerative Diseases.- Structure and Function of Soluble NCAM.- Theme III: Responses of Nervous Tissue to Trauma.- The Role of Schwann Cells in Peripheral Nervous System Regeneration.- Regeneration of Somatic Nerves in Permeable and Impermeable Tubes.- Role of Factors Intrinsic and Extrinsic to CNS Regulating Intra-Spinal Degenerative-Atrophy Following Sciatic Nerve Injury.- Intraspinal Sprouting of Primary Afferents After Spinal Denervation and Treatment with Antibodies to Nerve Growth Factor.- Role of Nerve Growth Factor in Neuronal Injury and Survival.- Glial-Derived Substances Associated with CNS Regeneration.- Neuronal Rescue in Cerebellar Cultures.- Axonal Regeneration in the Context of Spinal Cord Trauma.- Neurofilament Processing in Trauma and Disease.- The Process of Reinnervation of CNS Neurons: Evidence for Local Synthesis of Synaptic Constituents at Postsynaptic Sites.- Ganglioside Treatment of Experimental Brain Injury.- Effects of Gangliosides and Fibroblast Growth Factor on Central Neurons in Cell Cultures of Rat Hippocampus and Cortex During Development and Regeneration In-Vitro.- Photochemically Induced Vascular Thrombosis (Photothrombosis): Central Nervous System Consequences and Clinical Possibilities.- Grafted Fetal Astrocytes Migrate From Host Thoracic Spinal Cord to Lumbar Cord and Medulla.- Theme IV: Neuronal Endocrine-Immune Interactions.- The Source and Distribution of Autonomic Nervous System Nerves and Receptors within the Thymus Gland.- Neuroendocrine Functions in Lymphoid Tissues.- Interactions Between Thymosins and Neuroendocrine Circuits.- Nerve Growth Factor and the Immune System.- Evidence for Lymphoid Cell Participation in Neuroendocrine Pathways.- Immune System Growth Factor Modulation of Neonatal Oligodendrocyte Growth In Vitro.- Poster Abstract.- An Investigation of the Role of Phosphatidyl Ionositol Turnover in the Regenerating Rabbit Peripheral Nerve Trunk.- Effect of EGF on the Labeling of Various RNA Species and of Proteins From Subcellular Fractions in Primary Rat Astroglial Cell Cultures.- Myelin Treated Macrophages Release Mitogen for Schwann Cells.- Comparative Structural Features of Nerve Growth Factor and its Receptor.- Fetal Spinal Cord Homografts Reduce Expected Hind Limb Deficits from Spinal Cervical Fasiculus Gracilis Lesion.- The Temporal Relation Between a Corneal Neurotrophic Factor and Corneal Nerve Regeneration.- Slow Axonal Transport in Nerve from Mice with a Genetic Myelin Deficiency (Trembler).- Behavioral and Immunological Changes in the Aging Rat.- Morphological and Biochemical Effects on Striatal Astrocytes after Co-Cultivation With Substantia Nigra Neurons In Primary Cell Culture.- Nerve Growth Factor-Mediated Induction of Choline Acetyltransfer-ASE in Fetal and Neonatal Rat Septal Cholinergic Neurons in Organotypic Culture.- The Developmental Expression of Glial Specific mRNAs in Cultured Rat Brain Cells Identified By In Situ Hybridization.- Influence of Neurotrophic Factors on the Phosphorylation of Extracellular Proteins.- Astrocyte Binding of Epidermal Growth Factor.- Schwann Cells Proliferate in Response to Non-Myelinated Axons.- Effects of Nerve Growth Factor and Monosialoganglioside GM1 on Forebrain Cholinergic Neurones.- Modulation of Neurite Growth by Gaba in Cell Culture.- Effects of an Alpha-2 Adrenergic Receptor Agonist in Spinal Rats.- Induction of the 68/72 kDa Heat-Stress Protein in Hydrogen Peroxide Toxicity.- Peripheral Nerve Grafts Implanted Into Rats CNS (Optic Nerve) Show Electrophoretic Patterns of Radiolabelled Fast Axonally Transported Proteins Similar to the Pattern seen in the Normal Host CNS Tract.- Differentiation of a Migratory Bipotential Glial Progenitor Cell in the Developing Rat Optic Nerve.- Neuronal Primary Cultures - A Characterization.- Transplants of NGF-RIGH Tissue Increases Survival and Regeneration of Axotomized Cholinergic Neurons in The Basal Forebrain.- Neurofilament Processing in Development and Transplantation.- Antioxidant Enzymatic Activities and Resistance to Oxidative Stress in Primary and Subcultured Rat Astroclial Cells.- Role of Ascorbate in Laminin Accumulation, Basement Membrane Deposition Acetylcholine Receptor Aggregation On Muscle.