Nanobiosensors have been successful for in vitro as well as in vivo detection of several biomolecules and it is expected that this technology will revolutionize point-of-care and personalized diagnostics, and will be extremely applicable for early disease detection and therapeutic applications. This book describes the emerging nanobiosensor technologies which are geared towards onsite clinical applications and those which can be used as a personalised diagnostic device. Biosensor technologies and materials covered include electrochemical biosensors; implantable microbiosensors; microfluidic technology; surface plasmon resonance-based technologies; optical and fibre-optic sensors; lateral flow biosensors; lab on a chip; nanomaterials based (graphene, nanoparticles, nanocomposites, and other carbon nanomaterial) sensors; metallic nanobiosensors; wearable and doppler-based non-contact vital signs biosensors; and technologies for smartphone based disease diagnosis.
Clinical applications of these technologies covered in this book include detection of various protein biomarkers, small molecules, cancer and bacterial cells; detection of foodborne pathogens; generation and optimisation of antibodies for biosensor applications; microRNAs and their applications in diagnosis for osteoarthritis; detection of circulating tumor cells; online heartbeat monitoring; analysis of drugs in body fluids; sensing of nucleic acids; and monitoring oxidative stress.
* Chapter 1: Gold nanoparticle-based electrochemical biosensors for biomedical diagnosis applications * Chapter 2: Development and application of microbiosensors for in-vivo diagnostics * Chapter 3: Electrochemical biosensors: fabrication and applications in biodiagnostics * Chapter 4: Microchip-based separation and detection methods for chemically and biologically valuable analytes * Chapter 5: Biosensors of in vitro detection of cancer and bacterial cells * Chapter 6: Biacore - a surface plasmon resonance-based technology * Chapter 7: Implantable microbiosensors: towards in vivo monitoring * Chapter 8: Nanomaterials based biosensors: a smart approach towards on-site clinical diagnosis * Chapter 9: Optical waveguide-based biosensor for label-free monitoring of living cells * Chapter 10: Optical biosensors for the detection of food borne pathogens * Chapter 11: Generation and optimisation of antibodies for biosensor applications * Chapter 12: Smartphone-based in vitro diagnostic technologies for personalized healthcare monitoring and management * Chapter 13: Lateral flow biosensors * Chapter 14: MicroRNAs and their applications in diagnosis for osteoarthritis * Chapter 15: Electrochemical capacitive biosensors for point-of-care diagnostics: principles and applications * Chapter 16: AC electrokinetics-based capacitive biosensor as a platform technology for on-site detection of biospecific interactions * Chapter 17: Fibre optical technology for monitoring and diagnostic applications * Chapter 18: Nanobiosensors for the detection of circulating tumor cells * Chapter 19: Design investigations for robust and continuous online heartbeat monitoring using wearable vs. Doppler-based non-contact vital signs biosensors * Chapter 20: Lab on a chip for point-of-care analysis of drugs in body fluids * Chapter 21: Hydrogel-based biosensors: fundamentals and applications * Chapter 22: Applications of graphene microelectrodes in clinical analysis * Chapter 23: Sensing of nucleic acids and cancer cells using nanostructure-SPR integrated with microfluidic chip * Chapter 24: Surface plasmon resonance based miniaturized biosensors for medical applications * Chapter 25: Methods for monitoring oxidative stress using conventional and advanced nanodiagnostics methods * Chapter 26: Metallic nanobiosensors for biological analysis and medical diagnostics * Chapter 27: Carbon nanomaterial based biosensors for onsite biomedical diagnosis * Chapter 28: Nanoparticle-based sensing of oligonucleotides and proteins