Main description:

Reactive oxygen (ROS), nitrogen (RNS), and sulfur (RSS) species are implicated in the pathogenesis of a variety of pathological conditions, including chronic infections, inflammatory disorders, cardiovascular diseases, neurodegenerative diseases, and cancer. Modulation of Oxidative Stress: Biochemical, Physiological and Pharmacological Aspects is edited by a stellar team of active researchers. The book explores the field using an interdisciplinary approach, including chemical, biological, physiological, pharmaceutical, pharmacological, and physicochemical perspectives.

The book is comprised of three main parts. The first one discusses the biochemical aspects of oxidative stress modulation. It opens with an introduction to the field by the Editors, followed by chapter two covering antioxidants as modulators against proteinopathies, chapter three on cutaneous physiological redox, and chapter four on ferroptosis and metabolism. Part two - physiological and pathophysiological aspects include a collection of chapters on relevant conditions, including aging, neurological diseases, cerebral cavernous malformation, maternal and early-life malnutrition, Alzheimer's disease, liver transplant, and cancer. Part three is dedicated to pharmacological aspects and includes chapters on phytotherapy, and flavonoids.

Modulation of Oxidative Stress: Biochemical, Physiological and Pharmacological Aspects is a strong reference for pharma researchers in academia and industry considering leveraging modulation of oxidative stress as a strategy for the development of new drugs. Biochemists and Nutritionists may also benefit of the foundational understanding of cellular redox processes laid out.

Contents:

PART I BIOCHEMICAL ASPECTS 1. Antioxidants as modulators of the Ubiquitin-proteasome system against aging and proteinopathies 2. The Cutaneous Physiological Redox: Essential to Maintain but Difficult to Define 3. Ferroptosis and metabolism

PART II PHYSIOLOGICAL AND PATHOLOGICAL ASPECTS 4. Regulation of Nrf2 Signaling Pathway and the Hallmarks of Aging: An Overview 5. Fluid redox biomarkers in neurological disease 6. KRIT1 and oxidative stress in Cerebral Cavernous Malformations 7. Effects of maternal and early life nutrition on redox homeostasis 8. Mitochondria-associated membranes (MAMs) as modulators of oxidative stress in Alzheimer's disease 9. Oxidative stress biomarkers in human health and disease 10. ROS modulation as potential target for liver resection and transplant 11. Modulation of cancer cell proliferation by interfering with metabolic ROS production 12. Omega-3 nutritional intervention as therapeutic coadjuvant approach to improve Rett Syndrome clinical and biochemical features 13. A glance on antioxidants: the role of sulfur amino acids in retinal disorders 14. Modulation of oxidative stress in psoriasis: Pathophysiology and therapy 15. Oxidative stress and antioxidant-based therapies in couple infertility

PART III PHARMACOLOGICAL ASPECTS 16. Applications of plant-derived products in phototherapy 17. Hopes and disappointments related to the use of flavonoids in therapeutical approaches