Main description:

This book is indispensable to researchers in fields as diverse as Molecular Biology and Biophysics. It covers the important role that mitochondria play in a variety of biochemical spheres. It analyses how mitochondria affect metabolic pathways, how they are active in the regulation of cytosolic constituents, and their role in initiating signal pathways. Also covered are the way mitochondria help to regulate apoptosis, and how they modulate cellular hypertrophy and proliferation. It gives an overview of the emergence of mitochondria as an important regulator of cell signaling, with a particular focus on their pathophysiology.

Contents:

Chapter 1: Mitochondrial Size and Shape: Effect of Shear Stress and Osmotic Stress Al Mehdi, University of South Alabama Chapter 2: Regulation of Fatty Acid Metabolism Lopaschuk, Edmonton Chapter 3: Regulation of Pyruvate Metabolism Denton, Bristol Chapter 4: Regulation of Citric Acid Cycle and NADH Shuttles Taegtyeyer, Houston Chapter 5: PPAR and Mitochondria Sudgen, London Chapter 6: Amino Acids and Mitochondria King, Bristol Chapter 7: Regulation of Electron Transport IE Hassinen, Finland Chapter 8: Mitochondrial K Channels O'Rourke, Johns Hopkins Chapter 9: Calcium Transport and Mitochondria King, Bristol Chapter 10: Mitochondrial Metabolite Transporters LaNoue, Penn State Chapter 11: Generation of Free Radicals by Mitochondria Turrens, South Alabama Chapter 12: Mitochondria DNA Damage and Repair Wilson, South Alabama Chapter 13: Mitochondrial Permeability Transition Pore Halestrap, Bristol Chapter 14: Mitochondrial Apoptosis Suleiman, Bristol and Schaffer, South Alabama Chapter 15: Necrosis and Mitochondria Steenbergen, North Carolina Chapter 16: Preconditioning and Mitochondria Cohen and Downey, South Alabama