Medical Epigenetics provides a comprehensive analysis of the importance of epigenetics to health management. The purpose of this book is to fill a current need for a comprehensive volume on the medical aspects of epigenetics with a focus on human systems, epigenetic diseases that affect these systems and modes of treating epigenetic-based disorders and diseases. The intent of this book is to provide a stand-alone comprehensive volume that will cover all human systems relevant to epigenetic maladies and all major aspects of medical epigenetics. The overall goal is to provide the leading book on medical epigenetics that will be useful not only to physicians, nurses, medical students and many others directly involved with health care, but also investigators in life sciences, biotech companies, graduate students and many others who are interested in more applied aspects of epigenetics. Research in the area of translational epigenetics is a cornerstone of this volume.
Section I: Overview 1. An Overview of Medical Epigenetics Trygve O. Tollefsbol Section II: Basic Principles of Epigenetics 2. DNA Methylation: Basic Principles Cynthia A. Moylan and Susan K. Murphy 3. Histone-deacetylases as a therapeutic target in neurodegenerative diseases Farahnaz Sananbenesi and Andre Fischer 4. Basic principles of noncoding RNAs in epigenetics Ilaria Panzeri, Grazisa Rossetti and Massimiliano Pagani Section III: General Medical Aspects of Epigenetics 5. Epidemiological Epigenetics in Medicine Alexander Vaiserman 6. Lifestyle and Preventive Medical Epigenetics Marcus V. Gomes 7. Environmental Medical Epigenetics: A Review of Epigenetically-induced Medical Risks Generated from Exposures in Our Air, Food, and Personal Products Rachel L. Miller 8. Behavioral Medical Epigenetics Olivia H. Cox and Richard S. Lee 9. Medical Epigenetics in Twins Joel C. Eissenberg 10. Epigenetic Biomarkers of Disease Philip D. Voyias, Abhilasha Patel and Ramesh P. Arasaradnam 11. Prognostic Epigenetics Anup Sharma, Eihab Abdelfatah, Maryam Al Eissa and Nita Ahuja Section IV: Epigenetics of System Disorders 12. Immune System Disorders and Epigenetics Stuti Mehta and Kate L. Jeffrey 13. Pulmonary Diseases and Epigenetics Hong Peng, Dandan Zong, Zijing Zhou and Ping Chen 14. Cardiovascular Disorders and Epigenetics Charbel Abi Khalil 15. Epigenomics of Intestinal Disease Daniel Rory Kelly and Theresa Alenghat 16. Epigenetics of Skin Disorders Shuaihantian Luo and Qianjin Lu 17. Epigenetics in Bone and Joint Disorders N. Altorok, S. Nada, V. Nagaraja and Bashar Kahaleh 18. Epigenetics of Muscle Disorders Viviana Moresi, Nicoletta Marroncelli, Eva Pigna and Sergio Adamo 19. Epigenetics of Psychiatric Disorders Marija Kundakovic 20. Epigenetic Alterations in Endocrine-dependent Cancers: Implications of Endocrine Dysfunctions Genevieve Deblois and Mathieu Lupien 21. Reproductive Disease Epigenetics Rafael Oliva* 22. Epigenetics in Ocular Medicine Verity F. Oliver, Katherine A. van Bysterveldt and Shannath L. Merbs* Section V: Multi-system Medical Epigenetics 23. Pediatric Diseases and Epigenetics Judith G. Hall* 24. Epigenetics of Infectious Diseases Kate L. Seib and Michael P. Jennings 25. Clinical Utility of Solid Tumor Epigenetics Soren Kristiansen and Gyorgy Soletormos 26. Epigenetic Control in Human Normal Follicular Thyroid Cells and in Thyroid Carcinoma Zeus Andrea Antonello and Carmelo Nucera 27. Epigenetics in Acute Myeloid Leukemia Cristina Giorgio, Carmela Dell'Aversana and Lucia Altucci 28. Epigenetic Regulation in Cancer Metastasis Huan Wang, Yukun Zhang, Adam Kriska and Hong Chen 29. Epigenetics in Exercise Science and Sports Medicine Philipp Zimmer, Alexander Schenk and Wilhelm Bloch 30. Epigenetic Mechanisms and Inheritance of Acquired Susceptibility to Disease Rajesh C. Miranda, Nihal A. Salem, Annette S. Fincher, Amanda H. Mahnke and Sasha G. Burrowes Section VI. Pharmacology of Epigenetics 31. Toxicology and Epigenetics Jian Tajbakhsh and Jatinder Singh 32. Pharmacoepigenomics Ramon Cacabelos and Clara Torrellas Section VII: Therapeutic Epigenetics 33. Therapeutics and DNA Methylation Inhibitors Sheena Bhalla and Shyamala C. Navada 34. Histone Deacetylase Inhibitors in Medical Therapeutics Pusoon Chun 35. NAD+-dependent Deacetylases and Medical Therapy Ashok Kumar, Louisa Ben-Aderet, Jinan Elayan and Mona Dvir-Ginzberg* 36. Experimental Approaches Towards Histone Acetyltransferase Inhibitors as Therapeutics H. Wapenaar and Frank J. Dekker 37. Histone Methylation Modifiers in Medical Therapeutics Patrick Trojer 38. Therapeutics of Epigenetic-based RNA molecules Costas Koufaris* and Vicky Nicolaidou 39. Natural Epigenetic-modifying Molecules in Medical Therapy Avinash Kumar, Nasir A. Butt and Anait S. Levenson 40. Outcome of Combining Epigenetic Drugs with Other Treatments in the Clinic Paromita Raha 41. Epigenetics of Pain Management Beverley Greenwood-Van Meerveld, Dawn Prusator, Casey Ligon, Anthony C. Johnson and Rachel D. Moloney 42. Personalized Epigenetics Michael Bitzer and Nisar P. Malek 43. Epigenetics and Regenerative Medicine: Neural and Skeletal Muscle Perspectives Constantin Heil and Daniela Palacios 44. Stem Cell Epigenetics in Medical Therapy Baoli Cheng, Liqi Shu and Peng Jin Section VIII: Medical Epigenetics: Future Prospects 45. Prospective Advances in Medical Epigenetics Junjie Xiao and Guoping Li