Main description:

Authors Nigel M. Hooper and Otto von Guericke, world leaders in protease research, have written the first book that focuses on recent data stemming from the structural determination of intramembrane-cleaving proteases (I-CLiPs). You get the latest findings concerning the various roles that these proteases play in biology and in the course of diseases such as Alzheimer's and viral infection.

Contents:

Chapter 1: THE SITE-2 PROTEASE AT TEN, Robert B. Rawson and Wei-ping Li; Chapter 2: SIGNAL PEPTIDE PEPTIDASES, Todd E. Golde, Criag Zwizinski, Andrew Nyborg; Chapter 3: GXGD-TYPE INTRAMEMBRANE PROTEASES, Harald Steiner, Christian Haass; Chapter 4: RHOMBOID INTRAMEMBRANE SERINE PROTEASES, SINISA URBAN; Chapter 5: PROTEASES OF THE RHOMBOID FAMILY IN THE YEAST SACCHAROMYCES CEREVISIAE, Elke Pratje; Chapter 6: y-SECRETASE AND ALZHEIMER'S DISEASE, Michael S. Wolfe; Chapter 7: y-SECRETASE MEDIATED PROTEOLYSIS: AT THE CUTTING EDGE OF NOTCH SIGNALING, Ma. Xenia G. Ilagan, Dilip Chandu and Raphael Kopan; Index.