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MORE ABOUT THIS BOOK
Main description:
Ghrelin is a 28-amino acid acylated peptide predominantly produced by the stomach. It displays strong GH-releasing activity mediated by the hypothalamus-pituitary GH secretagogue (GHS)-receptors specific for synthetic GHS. Ghrelin also acts on other central and peripheral receptors and enables other actions including: stimulation of lactotroph and corticotroph secretion; food-intake; gastro-entero-pancreatic functions; metabolic; cardiovascular activity; and anti-proliferative effects. This volume aims to highlight the impact and function of the hormone ghrelin and provide insight to neuroendocrinologies and researchers interested in its molecular and clinical relevance.
Contents:
Contents
List of Contributors
Preface
1. Historical Milestones; C.Y. Bowers
2. Discovery of Ghrelin, an Endogenous Ligand for the Growth-Hormone Secretagogue Receptor; M. Kojima, H. Hosoda, H. Kaiya and K. Kangawa
3. Known and Unknown Growth Hormone Secretagogue Receptors and their Ligands; G. Muccioli, F. Broglio, E. Tarabra and E. Ghigo
4. Ghrelin: A New Link Between the Neuroendocrine Control of the GH Axis, Food Intake and Sleep; V. Tolle and the INSERM-ATC Nutrition Research Group on Ghrelin
5. Growth Hormone Releasing Activity of Ghrelin; C. Dieguez, F. Cordido, V. Popovic and F.F. Casanueva
6. Non-Growth Hormone Endocrine Actions of Ghrelin; M. Korbonits and A.B. Grossman
7. Ghrelin Food Intake and Energy Balance; M.H. Tschoep, T. Castaneda and U. Pagotto
8. Cardiovascular Activities of Ghrelin and Synthetic GHS; J. Isgaard, I. Johansson and A. Tivesten
9. Ghrelin: Central Actions and Potential Implications in NeuroDegenerative Diseases; R.G. Smith, Y. Sun, A.R.T. Bailey and A. Paschali
10. Ghrelin and Tumors; M. Papotti, C. Ghe, M. Volante and G. Muccioli
11. Metabolic Actions of Ghrelin; C. Gauna and A.J. van der Lely
12. Gastro-Entero-Pancreatic Actions of Ghrelin; Y. Date, M. Nakazato, K. Kangawa and H. Matsuo
13. A New Interaction to Come: Ghrelin and Steroid Hormones; U. Pagotto, A. Gambineri, V. Vicennati and R. Pasquali
14. Circulating Ghrelin Levels in Pathophysiological Conditions; D.E. Cummings and J. Overduin
15. Ghrelin Measurement: Present and Perspectives; H. Hosoda and K. Kangawa
16. Ghrelin: Implications in Pediatric Endocrinology; S. Bellone, A. Rapa, F. Broglio and G. Bona
17. Ghrelin and its Analogues: Perspectives for a Story of Reverse Pharmacology; E. Ghigo
Index
PRODUCT DETAILS
Publisher: Springer (Springer-Verlag New York Inc.)
Publication date: May, 2013
Pages: 257
Weight: 421g
Availability: Available
Subcategories: Diseases and Disorders, Endocrinology
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