Main description:

Experimental Hematology Today - 1988 presents the latest results of research reflecting the diverse interests of basic and clinical hematologists. The major areas explored are hematopoietic regulation by cytokines; hematopoietic cellular growth regulation, with emphasis on the interaction of stromal with hematopoietic stem and progenitor cells; granulopoietic regulators; gene transfers into hematopoietic progenitor cells; leukemogenesis; and bone marrow transplantation. All chapters report on research or clinical findings of the past year.

Contents:

1 Interleukin 1 in Hematopoiesis.- 2 Regulation of Human B Cell Growth.- 3 Mouse Bone Marrow Cells Which Require Multiple Growth Factors for Proliferation: Examination of the Effects of Interleukin 1, Serum Factors and Inhibitor(s).- 4 Role of NK Cells in Tumor Cell Growth and Eradication.- 5 A Quantitative Assay for Stroma Dependent Hemopoiesis.- 6 Matrix Glycoproteins May Regulate the Local Concentrations of Different Hemopoietic Growth Factors.- 7 Binding of Growth Factors to Heparan Sulphate: Implications for the Regulation of Hemopoiesis by Bone Marrow Stromal Cells.- 8 Aberrant Expression of GM-CSF in Transgenic Mice.- 9 Granulocyte Colony-Stimulating Factor.- 10 Regulation of Granulocyte-Macrophage Colony-Stimulating Factor in Murine Lymphocytes.- 11 Gene Transfer by Electroporation.- 12 Improved Retroviral Transfer of Genes into Canine Hematopoietic Progenitor Cells.- 13 The Use of Retroviral Vectors in Human Disorders.- 14 Towards Gene Therapy for Adenosine Deaminase Deficiency.- 15 Abnormal Gene Expression as an Early Indicator of Relapse in Acute Myelogenous Leukemia (AML).- 16 Gene Transfer in Canine and Feline Hematopoietic Progenitor Cells with Retroviral Vectors.- 17 Introduction of the Erythropoietin Gene to a Factor-Dependent Murine Myeloid Cell Line.- 18 Transforming Growth Factor ?: A Negative Regulator of Normal and Leukemic Hematopoietic Progenitor Cell Growth.- 19 The Regulation of Blast Stem Cell Self-Renewal in Myeloblastic Leukemia.- 20 Role of Hemopoietic Growth Factors in the Proliferation of Acute Myeloid Leukemia.- 21 Alterations in Dependence on Lipoxygenase Metabolism in Myeloid Leukemia.- 22 How to Prevent a Leukemia Relapse after Bone Marrow Transplantation in Acute Leukemia: Preclinical and Clinical Model Studies.- 23 Allogeneic Marrow Transplantation.- 24 Autologous Bone Marrow Transplantation for Acute Leukemia in Remission: Fifth European Survey. Results of 1021 Cases.- 25 Modern Trends in Autologous Bone Marrow Transplantation.- 26 High Dose Therapy and Autologous Bone Marrow Transplantation in Non Hodgkin's Lymphoma and Neuroblastoma.- 27 The Role of Hematopoietic Growth Factors in Nuclear and Radiation Accidents.