Main description:

Epidemiology of Cannabis: Genotoxicity, Neurotoxicity, Epigenomics and Aging examines cannabis epidemiology as it relates to adult and childhood neurotoxicity and genotoxicity as expressed in adult mental illness and childhood autism, adult and pediatric cancers and childhood congenital anomalies. The book provides information on major neurotoxicity and genotoxic outcomes in adults and children. Each chapter aims to demonstrate, through epidemiological analysis, the health implications from cannabis use. Parallels are explored between long-term cannabis exposure and mental illness, Autistic Spectrum Disorder, congenital anomalies, and cancer.

Contents:

SECTION 1: Mental Illness Close Parallels between Cannabis Use and Deteriorating US Mental Health at Four Levels Supports and Extends the Epidemiological Salience of Demonstrated Causal Mental Health Relationships: A Geospatiotemporal Study 1. National Trends 2. Regional Trends 3. State Trends 4. Sub-State Trends 5. Geospatial Analysis 6. Causality Criteria

SECTION 2: Autistic Spectrum Disorder Linked Rise of Cannabis Use and Autism Incidence Demonstrated by Close Three Level Geospatiotemporal Relationships, USA, 1990-2011. 7. National Trends 8. Regional Trends 9. State Trends 10. Geospatial Analysis 11. Changes in State Trends 12. Legal Status and Autism 13. Geospatial Analysis of Legal Status and Autism

SECTION 3: Congenital Anomalies Geotemporospatial Analysis of United States 38-44 Congenital Anomalies as a Function of Multiple Cannabinoid- and Substance- Exposure in the Decades of Cannabis Legalization: Phenocopying Thalidomide and Hundred Megabase-Scale Genotoxicity 14. Drug Use by Race 15. Drugs and Defects Overview 16. Chromosomal Anomalies: Anomalies 1:5 17. Gastroschisis: Anomaly 6 18. Atrial Septal Defect (Secundum): Anomaly 7 19. Cardiovascular Defects of Interest: Anomalies 8-11 20. Hawaiian - American Review: Anomalies 12-37 21. Conclusion: Time Course, Quintile Analysis, Canada, Thalidomide, Legal Status, Causality

SECTION 4: Cancer and Heritable Cancer Reflections of Heritable Cannabis-Related Genotoxicity in Rising Adult and Pediatric Cancer Rates Across USA in Time- and Ethnicity- Denominated Analyses 22. General Introduction and Overview 23. Sequential Analysis of Cancer Types 24. Geospatiotemporal Modelling - Fitted Values 25. Geospatiotemporal Modelling - Matrix Multiplication 26. Summary of Geospatiotemporal Modelling 27. Overall Conclusions

SECTION 5: Epigenetics and Aging As modern epigenetic studies provide profound insights into the observed pattern of teratological, cancerogenic and age-accelerated disease it becomes important to consider new findings in detail. 28. Epigenetics of Cannabinoids - Introduction 29. Epigenetics of Cannabinoids - Historical Studies 30. Epigenetics of Cannabinoids - Longitudinal Sperm Study - Overview 31. Epigenetics of Cannabinoids - Longitudinal Sperm Study - Stem Cells 32. Epigenetics of Cannabinoids - Longitudinal Sperm Study - Chromosomes 33. Epigenetics of Cannabinoids - Longitudinal Sperm Teratology - Brain 34. Epigenetics of Cannabinoids - Longitudinal Sperm Teratology - Cardiovasculature 35. Epigenetics of Cannabinoids - Longitudinal Sperm Teratology - Other Organs 36. Epigenetics of Cannabinoids - Longitudinal Sperm Study - Carcinogenesis 37. Epigenetics of Cannabinoids - Accelerated Aging