Main description:

With contributions by international experts in academia, chemical manufacturing, government research laboratories, regulatory agencies, and private consulting, this guide explores the potentially damaging influence of environmental agents on the endocrine system. It examines endocrine toxicology's increased importance in environmental safety issues due to legislative directives established over the past ten years.

Covering all principal areas of EPA concern, Endocrine Toxicology, Third Edition provides:

putative endocrine disruptors and mechanisms of endocrine toxicity
the history and status of the regulatory process
mechanisms of toxic effects in various hormonal systems
comparisons of the endocrine responses in humans, livestock, and wildlife
testing methods in mammalian, fish, avian, and amphibian models
valuable insight into the approaches of various personnel in the field, including: government officials who make and oversee policy; scientists in charge of development and validation of testing methods; basic researchers who identify toxic mechanisms; and manufacturers responsible for environmentally benign product certification

Contents:

Regulation of Endocrine Disruptive Chemicals in the United States. Pursuit of Endocrine Disruptors in Europe - the OECD Component. Impact of Endocrine Disruptor Policies and Regulations. The Hypothalamic-Pituitary-Gonadal Axis in Teleost Fish. The Hypothalamic-Pituitary-Gonadal Axis in Anuran Amphibians. The Hypothalamic-Pituitary-Gonadal Axis in Birds. The Hypothalamic-Pituitary-Gonadal Axis in Mammals. Comparing and Contrasting the Hypothalamic-Pituitary-Gonadal Axis in Different Vertebrate Classes. Male Reproductive Endpoints and the Rodent Hershberger Assay. Review of Bisphenol A by the National Toxicology Program. Pubertal Screening Assays in Rodents. Endocrine Disruption at Neuroendocrine and Neurotransmitter Sites. Endocrine Disruptor Interaction with Estrogen Receptors. Analysis of Endocrine Disruptors with Estrogen Reporter Systems. Time Dependent Embryotoxicity of the Endogenous Luteolysin, Prostaglandin F2alpha, in Ruminants. Actions of Endocrine Disruptors on the Thyroid Axis. Endocrine Disruption of Hormone Storage and Transport. Metal Toxicity in Mammalian Reproduction. Structure-Activity Modeling of Endocrine Disruptors. Overview of Endocrine Disruptor Ecotoxicity in Wildlife. Overview of USEPA Tests with Aquatic Vertebrates for Detecting and Assessing Endocrine Disrupting Chemicals. Biological Activity of Endocrine Disruptors in Aquatic Systems. Impact of Endocrine Disruptors on the Water Industry.