Main description:

The International Life Sciences Institute (ILSI) was creat ed to promote cooperative efforts toward solving critical health and safety questions involving foods, drugs, cosmet ics, chemicals, and other aspects of the environment. The officers and trustees believe that questions regarding health and safety are best resolved when government and industry rely on scientific investigations, analyses, and reviews by independent experts. Further, the scientific aspects of an issue should be examined and discussed on an international basis, separate from the political concerns of individual companies. The Institute is pleased to sponsor this set of monographs on pathology of laboratory animals. This project will help to improve the scientific application of the techniques of pathology to the evaluation of substances in our environ ment. The worldwide distribution of the authors, editors, and editorial board encourages the expectation that inter national communication and cooperation will also be strengthened. Alex Malaspina President International Life Sciences Institute Preface This book on the endocrine system is Volume I of a set of reference books on pathology of laboratory animals, prepared by the Interna tional Life Sciences Institute in response to recommendations from its Committee on Pathology and Toxicology. One aim is to provide infor mation which will be useful to pathologists, especially those involved in studies on the safety of foods, drugs, chemicals, and other sub stances in the environment.

Contents:

The Adrenals.- Embryology and Histology.- Embryology, Adrenal Gland, Mouse.- Histology, Adrenal Gland, Mouse.- Accessory Adrenocortical Tissue, Mouse.- Accessory Adrenocortical Tissue, Rat.- Hyperplasia and Neoplasia.- Hyperplasia, Adrenal Medulla, Rat.- Pheochromocytoma, Adrenal Medulla, Rat.- Pheochromocytoma, Adrenal Medulla, Mouse.- Ganglioneuroma, Adrenal, Rat.- Neuroblastoma, Adrenal, Rat.- Focal Hyperplasia, Adrenal Cortex, Rat.- Adenoma, Adrenal Cortex, Rat.- Adenocarcinoma, Adrenal Cortex, Rat.- Adenoma and Carcinoma, Adrenal Cortex, Mouse.- Nonneoplastic Lesions.- Amyloidosis, Adrenal, Mouse.- Lipogenic Pigmentation, Adrenal Cortex, Mouse.- Lipogenic Pigmentation, Adrenal Cortex, Rat.- Subcapsular-Cell Hyperplasia, Adrenal, Mouse.- Chemically Induced Adrenocortical Lesions.- Nodular Cortical Hyperplasia, Adrenal, Thymectomized Mouse.- Lipid Hyperplasia, Adrenal Cortex, Rat.- Lesions Due to Infections.- Mouse Hepatitis Viral Infection, Adrenal, Mouse.- Adenovirus Infection, Adrenal, Mouse.- Murine Cytomegalovirus Infection, Adrenal, Mouse.- Polyoma Virus Infection, Adrenal, Mouse.- Lymphocytic Choriomeningitis Virus Infection, Adrenal, Mouse.- The Pituitary.- Overview.- Functional and Pathologic Interrelationships of the Pituitary Gland and the Hypothalamus.- Histology, Ultrastructure, and Immunocytochemistry.- Pituitary Gland, Rat.- Hyperplasia and Neoplasia.- Histochemical Identification of Hormones in Pituitary Tumors, Rat.- Adenoma and Carcinoma, Pars Distalis, Rat.- Christian L. Gries Adenoma, Pars Intermedia, Anterior Pituitary, Rat.- Craniopharyngioma, Pituitary Gland, Rat.- Pituitary Tumors Induced by Estrogen, Rat.- Pituicytoma, Neurohypophysis, Rat.- Nonneoplastic Lesions.- Cysts, Pituitary; Rat, Mouse, and Hamster.- Inflammation, Pituitary; Rat, Mouse, and Hamster.- Cystoid Degeneration, Anterior Pituitary, Mouse.- The Thyroid.- Histology.- Ectopic Thyroid, Mouse.- Ectopic Thyroid, Rat.- Ectopic Thymus, Thyroid, Rat.- Hyperplasia and Neoplasia.- Follicular Cell Hyperplasia, Thyroid, Rat.- Follicular Cell Adenoma, Thyroid, Rat.- Follicular Cell Carcinoma, Thyroid, Rat.- Adenoma, Thyroid, Mouse.- Carcinoma, Thyroid, Mouse.- C-Cell Hyperplasia, Thyroid, Rat.- C-Cell Adenoma, Thyroid, Rat.- Medullary Carcinoma, Thyroid, Rat.- Goiter, Adenoma, and Carcinoma of the Thyroid Induced by Amitrole and Ethylenethiourea, Rat.- Nonneoplastic Lesions.- Lymphocytic Thyroiditis, Rat.- The Parathyroids.- Overview: Function and Structure.- Structural and Biochemical Aspects of Parathyroid Gland Function in Animals.- Parathyroid Glands, Hamster, Introduction.- Histology.- Anatomy, Histology, Parathyroid, Hamster.- Anatomy, Histology, Ultrastructure, Parathyroid, Mouse.- Anatomy, Histology, Ultrastructure, Parathyroid, Rat.- Ectopic Parathyroid, Mouse.- Hyperplasia and Neoplasia.- Hyperplasia, Parathyroid, Hamster.- Hyperplasia, Parathyroid, Rat.- Adenoma, Carcinoma, Parathyroid, Hamster.- Adenoma, Carcinoma, Parathyroid, Rat.- Nonneoplastic Lesions.- Cysts, Parathyroid, Hamster, Rat, Mouse.- The Pancreatic Islets.- Hyperplasia and Neoplasia.- Hyperplasia, Adenoma and Carcinoma of Pancreatic Islets, Mouse.- Pancreatic Islet-Cell Hyperplasia, Golden Hamster.- The Hypothalamus.- Technical Aspects in the Study of Pathologic Lesions in the Hypothalamus of the Rat.- Stereotaxic Map, Cytoarchitectonic and Neurochemical Summary of the Hypothalamic Nuclei, Rat.- Hypothalamic Lesions Associated with Streptozotocin Diabetes, Rat.- The Pineal Gland.- Histology, Ultrastructure, Pineal Gland, Rat.- Pinealoma, Rat.