Main description:

Approximately 10 years have elapsed since the first volume of the International Life Sciences Institute (ILSI) Monographs on Pathology of Laboratory Animals, Endocrine System was completed. New information of interest to pathologists has developed at a rather remarkable pace during the intervening years. Exceptional progress has been made in the routine identification of cell products in endo crine cells. A better understanding has developed of the mechanisms involved in cell metabolism, particularly involving toxins and car cinogens. Clear concepts have developed concerning the significance of some pathologic lesions in the endocrine system and their relation to human health and risk assessment. Standardized nomenclature has developed significantly during the 1O-year period since the first volume and is being utilized on an international basis. This has resulted in significant improvement in communication of pathologic data to regulatory agencies and in scientific publications worldwide. This monograph series and others sponsored by ILSI have produced a significant effect on improved communications and the international acceptance of standardized nomenclature. In this second edition, new formats have been used where more appropriate for the subjects to be covered. In many cases, the format used in the first edition still is useful. It is still necessary to recognize the morphologic features of pathologic lesions in order to identify them precisely, an essential step toward development of new insights into pathogenetic mechanisms and their use in decisions eventually applicable to public health.

Contents:

Pituitary.- Functional and Pathologic Interrelationships of the Pituitary Gland and Hypothalamus in Animals.- Histology, Ultrastructure, and Immunocytochemistry, Pituitary Gland, Rat.- Function and Morphology of the Rat Pituitary Gland, Combined Investigations by Means of an In Vitro Model.- Modern Approaches to Classification of Pituitary Tumors in Human Subjects and Animals.- Histochemical Identification of Hormones in Pituitary Tumors, Rat.- Adenoma and Carcinoma, Pars Distalis, Anterior Pituitary Gland, Rat.- Adenoma, Pars Intermedia, Anterior Pituitary, Rat.- Craniopharyngioma, Pituitary Gland, Rat.- Pituitary Tumors Induced by Estrogen, Rat.- Pituicytoma, Neurohypophysis, Rat.- Gangliocytoma, Pituitary Gland, Rat.- Pituitary Gland in the Human Growth-Releasing Factor Transgenic Mouse.- Cysts, Pituitary, Rat, Mouse, and Hamster.- Inflammation, Pituitary Gland: Rat, Mouse, and Hamster.- Cystoid Degeneration Due to Diethylstilbestrol, Anterior Pituitary, Mouse.- Craniopharyngeal Derivatives in the Neurohypophysis, Rat and Hamster.- Hypothalamus.- Stereotaxic Map, Cytoarchitectonic and Neurochemical Summary of the Hypothalamic Nuclei, Rat.- Study of Pathologic Lesions in the Hypothalamic-Pituitary System, Rat.- Hypothalamic-Pituitary Lesions Associated with Diabetes and Aging, Rat.- Hypothalamic-Pituitary-Adrenal Axis of Genetically Obese fa/fa Rats.- Pineal Gland.- Functional Morphology of the Mammalian Pineal Gland.- Tumors of the Pineal Gland, Rat.- Thyroid.- Hormonal Imbalances and Mechanisms of Chemical Injury of Thyroid Gland.- Ectopic Thyroid, Mouse.- Ectopic Thyroid, Rat.- Ectopic Thymus, Thyroid, Rat.- Follicular Cell Hyperplasia, Adenoma, and Carcinoma, Thyroid, Rat.- Adenoma and Carcinoma, Thyroid Follicular Cell, Mouse.- C-Cell Hyperplasia, C-Cell Adenoma, and C-Cell Carcinoma, Thyroid, Rat.- Goiter, Nodular Hyperplasia, Adenoma, and Carcinoma of the Thyroid Induced by Amitrole and Ethylenethiourea, Rat.- Ganglioneuroma, Thyroid Gland, Rat.- Lymphocytic Thyroiditis, Rat.- Parathyroids.- Pathobiology of Parathyroid Gland Structure and Function in Animals.- Anatomy, Histology, and Ultrastructure, Parathyroid, Syrian Hamster.- Anatomy, Histology, and Ultrastructure, Parathyroid, Mouse.- Anatomy, Histology, Ultra structure, Parathyroid, Rat.- Ectopic Parathyroid, Mouse.- Hyperplasia, Parathyroid, Syrian Hamster.- Hyperplasia, Parathyroid, Rat.- Adenoma, Parathyroid, Syrian Hamster.- Adenoma, Carcinoma, Parathyroid, Rat.- Pancreatic Islets.- Hyperplasia, Adenoma, and Carcinoma of Pancreatic Islets, Mouse.- Pancreatic Islet-Cell Hyperplasia, Golden Hamster.- Adenoma and Carcinoma, Pancreatic Islets, Rat.- Adrenals.- Embryology, Adrenal Gland, Mouse.- Histology, Adrenal Gland, Mouse.- Accessory Adrenocortical Tissue, Mouse.- Accessory Adrenocortical Tissue, Rat.- Immunohistochemical and In Situ Hybridization Analysis of Steroidogenic Enzymes for Study of Steroid Metabolism in Endocrine Organs.- Cell Proliferation in the Adult Adrenal Medulla: Chromaffin Cells as a Model for Indirect Carcinogenesis.- Hyperplasia and Pheochromocytoma, Adrenal Medulla, Rat.- Adrenal Medullary Tumors, Mouse.- Ganglioneuroma, Adrenal, Rat.- Neuroblastoma, Adrenal, Rat.- Focal Hyperplasia, Adrenal Cortex; Rat.- Adenoma, Adrenal Cortex, Rat.- Adenocarcinoma, Adrenal Cortex, Rat.- Adenoma and Carcinoma, Adrenal Cortex, Mouse.- Amyloidosis, Adrenal, Mouse.- Lipogenic Pigmentation, Adrenal Corex, Mouse.- Lipogenic Pigmentation, Adrenal Cortex, Rat.- Subcapsular-Cell Hyperplasia, Adrenal, Mouse.- Chemically Induced Adrenocortical Degenerative Lesions.- Nodular Cortical Hyperplasia, Adrenal, Thymectomized Mouse.- Lipid Hyperplasia, Adrenal Cortex, Rat.- Mouse Hepatitis Viral Infection, Adrenal, Mouse.- Adrenovirus Infection, Adrenal, Mouse.- Murine Cytomegalovirus Infection, Adrenal, Mouse.- Polyoma Virus Infection, Adrenal, Mouse.- Lymphocytic Choriomeningitis Virus Infection, Adrenal, Mouse.- Adrenal Necrosis Due to Besnoitiosis, Golden Hamster.