Main description:

Leon Chesley's Hypertensive Disorders in Pregnancy was initially published in 1978. Four decades later, hypertension complications in pregnancy are still a major cause of fetal and maternal morbidity and death, especially in less developed nations. It is also a leading cause of preterm birth now known to be a risk factor in remote cardiovascular disease. Despite this, hypertensive disorders remain marginally studied and management is often controversial. Chesley's Hypertensive Disorders in Pregnancy, Fifth Edition continues its tradition as one of the beacons to guide the field of preeclampsia research, recognized for its uniqueness and utility. This revision focuses on prediction, prevention, and management for clinicians, and is an essential reference text for clinical and basic investigators alike. It provides a superb analysis of the multiple topics that relate to hypertension in pregnancy, especially of preeclampsia.

Contents:

1. The Spectrum of Hypertensive Disorders in Pregnancy: Dr. Leon Chesley's Legacy

2. Epidemiology of Pregnancy-Related Hypertension

3. Genetic Factors in the Etiology of Preeclampsia/Eclampsia

4. Preconceptional and Periconceptional Pathways to Preeclampsia

5. Placentation and Placental Function in Normal and Preeclamptic Pregnancies

6. Unbiased Approaches for Addressing the Complexities of the Placenta's Role in the Preeclampsia Syndrome

7. The Immunology of Preeclampsia

8. Trophoblast Extracellular Vesicles in Preeclampsia

9. Angiogenesis and Preeclampsia

10. Vascular Endothelial Cell Dysfunction in Preeclampsia

11. Cardiovascular Alterations in Normal and Preeclamptic Pregnancy

12. Cardiometabolic Antecedents of Preeclampsia

13. Cerebrovascular Pathophysiology in Preeclampsia and Eclampsia

14. The Kidney in Normal Pregnancy and Preeclampsia

15. Salt, Aldosterone, and the Renin- Angiotensin System in Pregnancy

16. Platelets, Coagulation, and the Liver

17. Clinical Management and Antihypertensive Treatment of Hypertensive Disorders of Pregnancy

18. Prediction and Prevention of Preeclampsia

19. Long-Term Effects of Preeclampsia on Mothers and Offspring

20. Animal Models Used for Investigating Pathophysiology of Preeclampsia and Identifying Therapeutic Targets

21. Harmonization of Data and Biobanks for Preeclampsia Research