Main description:

This book presents a well-balanced view of the potential medical use of cannabinoids in pain. It comprehensively covers the current challenges with medical cannabis utilization and provides recommendations for research and future directions.

Organized into nine sections, the book begins with an introduction to medical cannabis, including its history, regulations, and the general attitudes of pain physicians on cannabis. Section two explores the biological effects of marijuana via the endocannabinoid system and its complex structure of receptors and enzymes. Sections three, four, and five then delve further into pharmacology and the mechanisms of action applicable to cannabinoids in managing pain.

Timely and socially conscious, section six examines the benefits of substituting opioids with cannabinoids for preoperative management. Echoing the book's well-rounded content, sections seven and eight consider the challenges with medical cannabis, including safety and quality control, brain development risks, vaping hazards, and withdrawal. The book then closes with a look at the future of cannabis in medical research.

Thoroughly and equitably composed, Cannabinoids and Pain is an invaluable resource for primary care physicians, pain and palliative care physicians, and oncologists.

Contents:

The demand for medical cannabis education

Cannabis Regulations

The Terminology

Cannabis Species and Chemotypes

THE ENDOCANNABINOID SYSTEM

The CB1 Receptors

The CB2 Receptors

Cannabinoids:

*Endocannabinoids: Anandamide and 2-AG

*Phytocannabinoids

*Tetrahydrocannabinol (THC)

*Cannabidiol (CBD)

Pharmaceutical Cannabinoids

*Dronabinol (Marinol)

*Nabilone (Cesamet)

*Cannabidiol (Epidiolex)

*Sativex (nabiximols)

Cannabinoid Metabolism

Medical Cannabis Dosing and Titration

Adverse events

Cannabinoids Drug interaction

CANNABINOIDS AND PAIN

Mechanisms of action

Clinical Evidence

The Challenges with Medical Cannabis

The Colorado Experience

THC paradoxical effects

Cannabis Concentrations

Cannabis labeling

Cannabis and brain development

Cannabis and mental health risks

Cannabis and child development during and after pregnancy

CANNABINOIDS AS A SUBSTITUTE FOR OPIOIDS

Basic science evidence

Observational and epidemiological evidence

Clinical evidence

FUTURE DIRECTIONS