Main description:

In the post-genomic era, cancer is a genetic disease. However, cancer genotype does not always equal cancer phenotype. Cancers with the same genetic abnormalities don't always behave the same. Understanding and eradicating cancers will require an appreciation for cancer's ecology.

This book is the first to comprehensively explore and critically appraise cancer microenvironments and host interactions with an eye towards exploiting our understanding for new treatments. The team of contributors share amongst them impressive experiences at the laboratory bench and in the clinic. These physician-scientists have dedicated themselves to the tension between the urgency for cures and the technical challenges of discovery.

The target audience includes clinical oncologists, clinical hematologists, research oncologists, research hematologists, immunologists, stem cell researchers, oncology and hematology fellows (trainees), oncology educators (graduate and undergraduate levels), and course book for graduate students and undergraduate students.

Contents:

Introduction; Cogle, Fiorentini, Baronzio Part 1. Tumor Physiopathology and Microenvironment Genesis 1. Inflammation and carcinogenesis: a change in the metabolic process; Schwartz 2. Tumour microenvironment. Aspects of stromal-parenchymal interaction; Zalatnai 3. Significance of tumor microenvironment on the genesis of : Interstitial Fluid, angiogenesis Hemostatic / Hemorheologic Abnormalities. Pathogenesis and therapeutic aspects; Baronzio et al. 4. Cancer Stem Cells in the Neoplastic Niche; Cogle Part 2. Tumor Microenvironment, Therapeutic Perspectives and Strategies for Normalization 5. Barriers to drug Delivery in cancer. Clinical implications; Baronzio et al. 6. Hypoxia, hyperthermia, chemotherapy: interactions and opportunities; Fiorentini, Baronzio 7. Effects of molecularly targeting hypoxia in oncology: part A) Theory- RCC as a model; part B) example of method for reducing side induced acute hypoxia by TACE for treating liver; Fiorentini et al. 8. Significance of tumour microenvironment on Radiotherapy; Horsman, Sieman 9. Effects of tumor microenvironment on Immunity. Clinical considerations; Baronzio, et al. 10. Effects Tumour microenvironment on hyperthermia, photodynamic and nanotherapy; Baronzio et al. 11. Vascular target agents from theory to practice. Suggestions for their use with hyperthermia; Gadaleta et al. 12. New indications for established drugs able to modify tumour-host interactions; Bundscherer, Hafner