Main description:

In the past decade there has been a major sea change in the way disease is diagnosed and investigated due to the advent of high throughput technologies, such as microarrays, lab on a chip, proteomics, genomics, lipomics, metabolomics etc. These advances have enabled the discovery of new and novel markers of disease relating to autoimmune disorders, cancers, endocrine diseases, genetic disorders, sensory damage, intestinal diseases etc. In many instances these developments have gone hand in hand with the discovery of biomarkers elucidated via traditional or conventional methods, such as histopathology or clinical biochemistry. Together with microprocessor-based data analysis, advanced statistics and bioinformatics these markers have been used to identify individuals with active disease or pathology as well as those who are refractory or have distinguishing pathologies. New analytical methods that have been used to identify markers of disease and is suggested that there may be as many as 40 different platforms. Unfortunately techniques and methods have not been readily transferable to other disease states and sometimes diagnosis still relies on single analytes rather than a cohort of markers. There is thus a demand for a comprehensive and focused evidenced-based text and scientific literature that addresses these issues. Hence the formulation of Biomarkers in Disease. The series covers a wide number of areas including for example, nutrition, cancer, endocrinology, cardiology, addictions, immunology, birth defects, genetics, and so on. The chapters are written by national or international experts and specialists.

Feature:

Bridges intellectual divides and useful for student nurses and advanced practitioners
Written by experts
Each chapter has an abstract, key facts, definition of words and terms, potential applications to other diseases conditions or prognosis, summary points
Fills a much needed gap to have a one volume “one-stop-shopping” synopsis of the scientific basis of biomarker discovery or application

Contents:

Biomarkers in Metastatic Colorectal Cancer.- CD163 and TARC as Disease Response Biomarkers in Hodgkin Lymphoma.- Expression Profiling as Biomarkers in Colorectal Serrated Adenocarcinoma.- Immunophenotypiing as Biomarker Platform in Leukemia.- Matrix metalloproteinase family as molecular biomarkers in oral tongue cancers.- Microarrays and Renal Cell Cancer Biomarkers.- Telomerase as Biomarker for Oral Cancer.- Telomerase as Biomarker in Colorectal Cancer.- U2 Small Nuclear RNA as Biomarker in Cancer.- Whole Blood Transcriptome as Biomarkers in Nasopharyngeal Cancer.