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Bone and Cancer
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Main description:

The fifth in a series of reviews, centered on a single major topic (vol. 1 Bone Formation, vol. 2 Bone Resorption, vol. 3 Engineering of Functional Skeletal Tissues, vol. 4 Osteoarthritis) written by acknowledged authorities in the field, and aimed at researchers, clinicians and others involved in the bone field.


With chapters written by authorities in the field, the reader will be made aware of the current status of the disease, appropriate treatment and a sense of where future research is likely to lead

Back cover:

Bone and Cancer is the fifth volume in the series Topics in Bone Biology, edited by Felix Bronner and Mary C. Farach-Carson. This title features current knowledge on mechanisms of metastasis, the role of the bone microenvironment in cancer progression, how inflammatory cytokines function in metastasis and osteolysis, and the role of osteoblasts, thus bringing to the clinician and researcher cellular and molecular findings that affect the search for drugs and lead to translational studies.

Each chapter contains an extensive bibliography that permits readers to learn more about specific aspects of the chapter topic.  Tables, diagrams and figures illustrate and clarify cellular events that lead to development and progression of cancer in bone. Insights based on cellular and molecular events clarify the clinical picture and may lead to translational research and focused therapy.  The chapters, authored by authorities from throughout the world, emphasize how current knowledge can lead to better treatement.

Other titles in this series:-

Bone Formation

Bone Resorption

Engineering of Functional Skeletal Tissues

Bone and Osteoarthritis


Blood–Bone Axis and Bone Marrow Microenvironment.- Genetics of Osteosarcoma.- Multiple Myeloma and Other Hematological Malignancies of Bone.- Mechanism of Metastasis to Bone: The Role of Bone Marrow Endothelium.- Lysophosphatidic Acid: Role in Bone and Bone Cancer.- Role of Bone Microenvironment/Metastatic Niche in Cancer Progression.- Detection and Characterization of Disseminated Tumor Cells present in Bone Marrow of Cancer Patients.- Molecular Imaging of Cancer Cells Growing in Bone.- Inflammatory Cytokines and Their Role in Bone Metastasis and Osteolysis.- Prostate Cancer Bone Colonization: Osteomimicry in the Bone Niche.- Bone Pain Associated with Cancer Metastasis.- Small Animal Models for the Study of Cancer in Bone.- Hormonal therapies in Breast and Prostate Cancer: Effects on Bone and the Role of Bisphosphonates.- Therapeutic Approaches to Metastatic Bone Cancer II: Targeted and Non-targeted Systemic Agents.- The Role of Allogeneic Bone Marrow Transplant in Cancer Treatment.- The Role of Radiosurgery in the Treatment of Bone Localized Cancers.


ISBN-13: 9781848820180
Publisher: Springer (Springer London)
Publication date: June, 2009
Pages: 256
Availability: Temporarily unavailable
Subcategories: Oncology, Orthopaedics and Fractures


Series Editors of Topics in Bone Biology are: Professors Felix Bronner, PhD - University of Connecticut Health Center, Farmington, CT, USA, and Dr Mary C. Farach-Carson, PhD - the Department of Biology, University of Delaware, Newark, DE, USA

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Average Rating 

From the reviews:

“This book covers the basic science and translational and clinical aspects of bone cancer and bone tumors. … The target audience is clearly an elite group of clinicians and scientists who are focused on understanding future innovations in the treatment of bone related cancers. … a great addition to the lab that is studying bone cancers or for the clinician who is actively treating patients with bone cancer. … the average orthopedist will find in deeper scientifically than is necessary for a general orthopedic practice.” (Mark R. Hutchinson, Doody’s Review Service, December, 2009)

“This book is the fifth volume in the series Topics in Bone Biology. It presents up to date knowledge in the mechanisms of cancer in bone. … The book is well written, extensively referenced and comprehensive. It has been well edited, and chapters are of a consistent layout. … The book will make a good addition to a departmental library in any unit managing skeletal cancer.” (Robert U. Ashford, European Journal of Orthopaedic Surgery & Traumatology, Vol. 21, 2011)