Main description:

Biomarkers of Hip Implant Function brings together established and potential new biomarkers, critically evaluating their clinical usefulness based on recent evidence. Researchers will benefit from a comprehensive view of the topic to identify underexplored areas. Orthopedic surgeons and general practitioners will use the book to monitor implant performance and facilitate management of their patients. Additionally, the work will benefit engineers and joint implant manufacturers to guide improvements in design. This book will also be of interest to regulators and policymakers by helping them update their guidelines on follow-ups for hip implant recipients.

Nearly all orthopedic surgeons have implanted a cobalt-chromium hip and most general practitioners have at least one patient with cobalt-chromium implant on their books. The recent worldwide controversy surrounding metal-on-metal hips means that advice on how to manage patients with these implants is of great interest to these professionals. Hence, this book is a welcomed addition to the conversation.

Contents:

Part I: Foundational information 1. Introduction to hip implants and biomarker testing Ilona Swiatkowska, Shiraz A. Sabah, Laura-Maria Horga and Alister J. Hart 2. Degradation of metal hip implants Andrew R. Beadling, Anne Neville and Michael G. Bryant 3. Implant metals and their potential toxicity Ilona Swiatkowska Part II: Assessing hip implant function and risk of local and systemic adverse reactions 4. Markers of hip implant degradation: analytical considerations and clinical interpretation Pascal-Andre Vendittoli, Angela Styhler and Ilona Swiatkowska 5. Biomarkers of compromised implant fixation Reshid Berber, Benjamin Bloch, Peter James and Andrew Manktelow 6. Biomarkers of periprosthetic joint infection Marc-Olivier Kiss and Vincent Masse 7. Hip implants and systemic cobalt toxicity: a comprehensive review with case studies Ilona Swiatkowska, Obakanyin J. Akinfosile, Ravindra V. Badhe, Mark Barba, Mathew T. Mathew and Divya Bijukumar Part III: Translational effect of biomarker research on clinical practice 8. Clinical guidelines on the use of biomarkers for surveillance of hip replacements Harry Hothi, Reshid Berber, Shiraz A. Sabah and Alister J. Hart