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Biomarkers
In Medicine, Drug Discovery, and Environmental Health
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Main description:

The quintessential introductory guide to the study andapplication of biomarkers

Most commonly associated with medical diagnostics, biomarkersindicate the presence of disease as well as determine its stage ofprogression. However, in addition to their role in detectingillness, biomarkers have important roles to play in other importantbiological and biochemical functions that are directly relevant tohealth, including predicting a drug′s toxicity or effectiveness,and providing a reliable parameter with which to measure one′sexposure to hazards in the environment.


A robust introduction to these versatile tools, this book coversthe basic fundamentals of biomarkers with discussion of theirvarious uses, then explores the different approaches that can beapplied in identifying, characterizing, and monitoring them. Asolid foundation for examining the principles, advantages,disadvantages, and applications of methods for biomarker discoverytechniques, this book:



  • Describes classical and novel biomarkers for different organdamage and disease states including HIV, cancer, neurodegenerativedisease, kidney and vascular injury

  • Emphasizes the preclinical and clinical manifestations ofinjury and disease processes and how these can be predicted andmonitored with biomarkers

  • Covers the approaches, diagnostics, and assays for detectingbiomarkers

  • Provides information on the U.S. FDA′s Critical PathInitiative, which has placed a high priority on the identificationand qualification of additional biomarkers


Biomarkers offers a wealth of material that will aidresearchers in choosing the correct biomarker for a given case,teach them how to accurately analyze and interpret their results,and guide them in making informed decisions concerning diagnosesand monitoring of tissue injury. For these reasons, students andprofessionals from many scientific fields will findBiomarkers a valuable addition to their referencelibrary.


Back cover:

The quintessential introductory guide to the study andapplication of biomarkers

Most commonly associated with medical diagnostics, biomarkersindicate the presence of disease as well as determine its stage ofprogression. However, in addition to their role in detectingillness, biomarkers have important roles to play in other importantbiological and biochemical functions that are directly relevant tohealth, including predicting a drug′s toxicity or effectiveness,and providing a reliable parameter with which to measure one′sexposure to hazards in the environment.


A robust introduction to these versatile tools, this book coversthe basic fundamentals of biomarkers with discussion of theirvarious uses, then explores the different approaches that can beapplied in identifying, characterizing, and monitoring them. Asolid foundation for examining the principles, advantages,disadvantages, and applications of methods for biomarker discoverytechniques, this book:



  • Describes classical and novel biomarkers for different organdamage and disease states including HIV, cancer, neurodegenerativedisease, kidney and vascular injury

  • Emphasizes the preclinical and clinical manifestations ofinjury and disease processes and how these can be predicted andmonitored with biomarkers

  • Covers the approaches, diagnostics, and assays for detectingbiomarkers

  • Provides information on the U.S. FDA′s Critical PathInitiative, which has placed a high priority on the identificationand qualification of additional biomarkers


Biomarkers offers a wealth of material that will aidresearchers in choosing the correct biomarker for a given case,teach them how to accurately analyze and interpret their results,and guide them in making informed decisions concerning diagnosesand monitoring of tissue injury. For these reasons, students andprofessionals from many scientific fields will findBiomarkers a valuable addition to their referencelibrary.


Contents:

Preface.

Contributors.


1 Biomarkers: An Evolutionary Perspective (Michael Fergusonand Vishal Vaidya).


SECTION I: TOOLS FOR BIOMARKER DISCOVERY.


2 Genomics (Weida Tong and Donna L. Mendrick).


3 Proteomics for Biomarker Discovery (Timothy D.Veenstra).


4 Metabolic Profiling for Biomarker Discovery (Hector C.Keun).


5 The Bittersweet Promise of Glycobiology (PadmaparnaChaudhuri, Rania Harfouche, and Shiladitya Sengupta).


SECTION II: BIOMARKERS OF INJURY/DISEASE.


6 Biomarkers of Alzheimer′s and Parkinson′s Disease (WalterMaetzler and Daniela Berg).


7 Biomarkers of Cardiac Injury (Anthony S. McLean and StephenJ. Huang).


8 Lung Injury Biomarkers (Urmila P. Kodavanti).


9 Translational Biomarkers of Acute Drug–Induced Liver Injury:The Current State, Gaps and Future Opportunities (Josef Ozer,William Reagan, Sheli Schomaker, Joe Palandra, Mike Baratta andShashi Ramaiah).


10 Biomarkers of Acute Kidney Injury (Frank Dieterle andFrank Sistare).


11 In Search of Biomarkers for Drug–Induced Vascular Injury(James R. Turk).


12 Biomarkers of Immunotoxicity (Rodney R. Dietert).


13 Biomarkers in Obstetric Medicine (Manish Maski, SaroshRana and S. Ananth Karumanchi.


14 Biomarkers in Cancer (Roopali Roy, Christine M. Coticchia,Jiang Yang and Marsha A. Moses).


15 Biomarkers of HIV (Lewis Kaufman and Michael JRoss).


16 Biomarkers of In Vitro Drug–Induced Mitochondrial Dysfunction(James A. Dykens and Yvonne Will).


SECTION III: TECHNOLOGY FOR BIOMARKER DETECTION.


17 Immunoassay–Based Technologies for the Measurement ofBiological Materials Used for Biomarkers Discovery andTranslational Research (Vincent Ricchiuti).


18 Nanoscale Techniques for Biomarker Quantification(Madhukar Varshney, and Harold G. Craighead).


19 Immunodiagnostics with a Focus on Lateral Flow Point–of–CareDevices (Roy R. Mondesire, Glen M. Ford, Hannie F. Ford, andStephen C. Mefferd).


SECTION IV: HOT TOPICS IN BIOMARKER RESEARCH.


20 Biomarkers for Environmental Exposure (Jane E. Gallagher,Elaine A. Cohen Hubal and Stephen W. Edwards).


21 Clinical Study Design in Biomarker Research (OrfeasLiangos and Bertrand L. Jaber).


22 Statistical Issues in Biomarker Research (Daniel Holderand Matthew Schipper).


23 Regulatory Perspective for Biomarker Qualification from U.S.FDA (Federico Goodsaid).


24 The European Medicines Agency Approach (Marisa PapalucaAmati and Spiros Vamvakas).


Index.


PRODUCT DETAILS

ISBN-13: 9780470452240
Publisher: John Wiley & Sons Ltd (Wiley–Blackwell)
Publication date: October, 2010
Pages: 602
Dimensions: 167.00 x 235.00 x 37.41
Weight: 1046g
Availability: Available
Subcategories: Diseases and Disorders, General Issues

MEET THE AUTHOR

VISHAL S. VAIDYA, PhD, is an Assistant Professor of Medicineat Harvard Medical School in the Renal Division of Brigham andWomen′s Hospital. He directs the Laboratory of Kidney Toxicologyand Regeneration with a research emphasis on discovery andevaluation of biomarkers and biosensors for early detection ofkidney injury and investigates the molecular mechanisms of kidneytissue repair. Dr. Vaidya has authored more than thirty–fiveoriginal research articles and twelve chapters and reviews. Heserves as a councilor for the northeast chapter of the Society ofToxicology and is an elected member of Harvard School of PublicHealth′s Center for Environmental Health. He is the recipient ofthe Pathway to Independence grant by the National Institute ofEnvironmental Health Sciences.

JOSEPH V. BONVENTRE, MD, PhD, is the Samuel A. LevineProfessor of Medicine at Harvard Medical School. He is also Chiefof the Renal Division and Director of the Biomedical EngineeringDivision of Brigham and Women′s Hospital and is President–elect ofthe American Society of Nephrology. He has authored more than 250original papers and 120 chapters and reviews. His research focusesprimarily on the study of kidney injury and repair and signaltransduction, with special emphasis on the role of inflammation,biomarkers, and stem cells. Bonventre has received a MERIT awardfrom the National Institute of Diabetes and Digestive and KidneyDiseases.

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