Main description:

Biology of Aminoacyl-tRNA Synthetases, Volume 48 in The Enzymes series, highlights new advances in the field, with this new volume presenting interesting chapters on A narrative about our work on the endless frontier of editing, The puzzling evolution of aminoacyl-tRNA synthetases, Structural basis of the tRNA recognition by aminoacyl-tRNA synthetases, Catalytic strategies of aminoacyl-tRNA synthetases, Trans-editing by aminoacyl-tRNA synthetase-like editing domains, Adaptive and maladaptive mistranslation arising from aminoacyl-tRNA synthetases, Non-canonical inputs and outputs of tRNA aminoacylation, Structure and function of multi-tRNA synthetase complexes, Mitochondrial aminoacyl-tRNA synthetases, Non-canonical functions of human cytoplasmic tyrosyl-, tryptophanyl- and other aminoacyl-tRNA synthetases, and much more.

Contents:

1. The endless frontier of tRNA synthetases

Paul Schimmel

2. The evolution of aminoacyl-tRNA synthetases: From dawn to LUCA

Lluis Ribas de Pouplana

3. Putting amino acids onto tRNAs: The aminoacyl-tRNA synthetases as catalysts

Rebecca W. Alexander and Tamara L. Hendrickson

4. Trans-editing by aminoacyl-tRNA synthetase-like editing domains

Alexandra B. Kuzmishin Nagy, Marina Bakhtina and Karin Musier-Forsyth

5. Noncanonical inputs and outputs of tRNA aminoacylation

Marine Hemmerle, Marion Wendenbaum, Guillaume Grob, Nathaniel Yakobov, Nassira Mahmoudi, Bruno Senger, Sylvain Debard, Frederic Fischer and Hubert Dominique Becker

6. Structures and functions of multi-tRNA synthetase complexes

Myung Hee Kim and Sunghoon Kim

7. Mitochondrial aminoacyl-tRNA synthetases

Joseph Chihade

8. Non-canonical functions of human tytoplasmic tyrosyl-, tryptophanyl- and other aminoacyl- tRNA synthetases

Keisuke Wakasugi and Takumi Yokosawa

9. Aminoacyl-tRNA synthetases in cell signaling

Peng Yao and Paul L. Fox

10. Human diseases linked to cytoplasmic aminoacyl-tRNA synthetases

Lei Jiang, Julia Jones and Xiang-Lei Yang

11. Aminoacyl-tRNA synthetases as drug targets

Maria Lukarska and Andres Palencia

12. Engineering aminoacyl-tRNA synthetases for use in synthetic biology

Natalie Krahn, Jeffery Tharp, Ana Crnkovic and Dieter Soell

13. Novel functions of cytoplasmic aminoacyl-tRNA synthetases shaping the hallmarks of cancer

Justin Wang and Xiang-Lei Yang