Written by leading experts in the field and designed for dermatologists and residents, this book includes evidence-based medicine that underscores the clinical data, as well as practical tips on how to use both biologic and systemic agents in the field of dermatology. In the past decade, there have been several groundbreaking advances in medical dermatology. Novel biologic and systemic agents have been developed to treat inflammatory disorders, including psoriasis and atopic dermatitis, as well as skin malignancies such as melanoma. Biologic and Systemic Agents in Dermatology encompasses these developments by describing the mechanism of action of these various agents and the clinical efficacy and safety to treating these respective disorders. The utilization of biologic and systemic agents in other dermatologic conditions, pharmacoeconomics, pharmacovigilance, and clinical trials outcomes are discussed as well as topics including tumor necrosis, conventional systemic agents for psoriatic disease, and oral agents for atopic dermatitis.
Chapter 1 - Tumor Necrosis Factor Inhibition in the Treatment of Psoriasis and Psoriatic Arthritis Chapter 2 - Therapies Targeting Interleukin-23 in Psoriatic Disease Chapter 3 - Interleukin 17 - Pathogenesis in Psoriatic Disease and Treatment through Selective Blockade Chapter 4 - Conventional Systemic Agents for Psoriatic Disease Chapter 5 - The Role of JAK Kinase Inhibitors in Psoriatic Disease and Other Dermatologic Conditions Chapter 6 - PDE4 Inhibition in the Treatment of Psoriasis Disease and Other Skin Conditions Chapter 7 - Miscellaneous Use of Biologic and Systemic Agents in Other Dermatologic Conditions Chapter 8 - Targeting Interleukin 4 and Interleukin 13 in the Treatment of Atopic Dermatitis Chapter 9 - Oral Agents for Atopic Dermatitis Chapter 10 - Role of Intravenous Immunoglobulin in Dermatologic Disorders Chapter 11 - Selective Targeting of CD20 on B Cells in Pemphigus Vulgaris and Other Dermatologic Diseases Chapter 12 - Oral Systemic Agents for Various Immunobullous Disorders Chapter 13 - Anti-IgE Therapy in Dermatology Chapter 14 - Oral Retinoids in Dermatology Chapter 15 - Updates in Immunotherapies for Melanoma Chapter 16 - Sonic Hedgehog Inhibition in the Treatment of Advanced BCC