Main description:

The topic of this Mosbach Colloquium was meant as a question to begin with. When I started to study differentiation and morphogenesis in Volvox I hoped for a straightforward answer along prepared groove- only to find out that also here things follow Murphy's Law: they were much more complicated than expected! Succour had to be sought. Thus, the idea arose to put this question before a board of experts. Experience would have warned any ex-service man never to utter an idea or else you would be made responsible, and it came as it had to come: I was made impressario of this gremium; I had to assemble the experts. These Proceedings contain their expertise. I cannot even say that I biased it by my picking. In the beginning I aimed at setting different accents by inclination and force of habit. Then, by trial and error, by advice and declination, the programme shaped itself. It eventually gained momentum of which also the size of this volume is indicative. In this volume are printed all the papers presented - with two regret ted exceptions - but not the sometimes lively discussion, which clari fied and pruned here and there. It would just have made the size too unwieldy. Differentiation and morphogenesis start with the expression of genes. The development programme reels off the genome and is regulated by the position of the appropriate genes. Their structure is in the focus of gene biochemistry since the decisive tools have become available.

Contents:

Gene Expression.- Synchrony of Gene Expression and Regulation of the Developmental Program in Normal and Leukemic Cells.- Structure and Tissue-Specific Expression of Members of the Mouse ?-Amylase Multigene Family.- Actin and Myosin Genes and Their Expression During Skeletal Muscle Myogenesis.- Regulation of Flavonoid and Phytoalexin Accumulation Through mRNA and Enzyme Induction in Cultured Plant Cells.- Regulation of Gene Expression During Embryonic Development.- The Yeast Mating Type System - A Model for the Regulation of Gene Expression by the Position of a Certain Gene Within the Genome?.- Expression of Gap Junction Protein in Liver and Lens Fiber Tissue.- Transfer of Genes.- Plant Cells Transformed by Modified Ti Plasmids: A Model System to Study Plant Development.- The Dualism of Expression of onc-Genes: Transformation versus Differentiation.- The Biology of an Oncogene, Based upon Studies on Neoplasia in Xiphophorus.- Involvement of tRNA and the Modified Nucleoside Queuosine in Cell Development and Differentiation.- Cell Differentiation.- Regulation of Bacterial Sporogenesis.- The Human Epsilon Globin Gene - A Paradigm for Erythroid Differentiation.- Erythrocyte Heterokaryons - A Model System for the Analysis of Cell Determination and Gene Regulation.- Regulation of Development of Salivary Glands in 3rd Instar Drosophila melanogaster Larvae by Ecdysone.- The Gene for Chicken Lysozyme: Structure and Expression of a Steroid Regulated Gene.- Regulation of Structural Sperm Protein Synthesis by Y Chromosomal Loci.- Cell Recognition.- Cell Recognition by Axonal Growth Cones in Vitro.- Muscle Transplantation in Mammals: A Tool to Study Neuromuscular Mutations and Specificity of Innervation.- Altered Cell Surface Glycosphingolipids of Murine Lymphocytes Belonging to Different Differentiation Pathways.- Morphogenesis.- Conjugation of Ciliates in Biochemistry of Multicellular Morphogenesis.- Molecules Involved in Morphogenesis in the Multicellular Stage of Dictyostelium discoideum.- Hormonal Control of Regeneration in Hydra.- Inflammatory Mediators and Wound Hormones: Chemical Signals for Differentiation and Morphogenesis in Tissue Regeneration and Healing.- Signals of Cell Determination in Embryogenesis.- Differentiation and Embryogenesis in Volvox carteri.