Main description:

Autophagy Dysfunction in Alzheimer's Disease and Dementia provides an overview for researchers and clinicians on the mechanisms involved in protein degradation in Alzheimer's. The book discusses the implication of autophagy dysfunction in these diseases and how it causes degenerated proteins, including aggregated tau and aggregated amyloid protein. Other sections explores the possibilities of potential drug development through autophagy modulation, making this a great resource on the study of how autophagy dysfunction has been linked to the accumulation of misfolded proteins that cause death of neurons in Alzheimer's and other neurodegenerative diseases.

Contents:

Section I. Degradation mechanisms of cells 1. Degradation mechanisms of cells

Section II. Lysosomes 2. Lysosomes-neuronal degeneration in lysosomal storage disorders

Section III. The autophagic pathways 3. The autophagy pathway and its key regulators

Section IV. Amyloid beta protein and autophagy 4. Basics of amyloid beta protein in Alzheimer's disease 5. Molecular linkages among Ass, tau, impaired mitophagy, and mitochondrial dysfunction in Alzheimer's disease 6. Endocytosis in ss-amyloid biology and Alzheimer's disease

Section V. Autophagy and tau protein 7. Autophagy and tau protein 8. BAG3 promotes tau clearance by regulating autophagy and other vacuolar-dependent degradative processes 9. Tau propagation and autophagy

Section VI. Autophagy and pathology in Alzheimer's disease 10. Granulovacuolar degeneration in neurodegeneration 11. Autophagy dysfunction in skeletal myopathies: Inclusion body myositis and Danon disease

Section VII. Autophagy and other disorders causing dementia 12. Autophagy in Lewy body diseases and multiple system atrophy 13. Autophagy and Huntington's disease

Section VIII. Drug discovery in Alzheimer's disease by modulating autophagy 14. Drug discovery in Alzheimer's disease by regulating autophagy 15. Drug discovery in Alzheimer's disease using metal chelators: Warning toward their uses 16. Development of autophagy enhancers for Parkinson's disease therapy